DXO

Gene Symbol DXO
Entrez Gene 1797
Alt Symbol DOM3L, DOM3Z, NG6, RAI1
Species Human
Gene Type protein-coding
Description decapping exoribonuclease
Other Description decapping and exoribonuclease protein|protein Dom3Z
Swissprots Q6IPZ2 Q5ST60 O15004 B0UZ80 Q9NPK4 O77932 O78127 A2CER3 O78128
Accessions AAB67983 CAB89305 CAB89306 EAX03558 EAX03559 EAX03560 EAX03561 EAX03562 EAX03563 EAX03564 EAX03565 O77932 AF059252 AAC78603 AF059253 AAC78604 AF059254 AAC78605 AK310107 BC009344 AAH09344 BC019083 AAH19083 BC030235 BC050618 BC058885 BC071651 DQ893041 ABM83967 DQ896284 ABM87283 XM_006715005 XP_006715068 XM_006715007 XP_006715070 XM_006725474 XP_006725537 XM_006725476 XP_006725539 XM_006725688 XP_006725751 XM_006725690 XP_006725753 XM_006725898 XP_006725961 XM_006725900 XP_006725963 XM_006725985 XP_006726048 XM_006725987 XP_006726050 XM_006726078 XP_006726141 XM_006726080 XP_006726143 XM_011547606 XP_011545908 XR_926081 XR_926082 XR_952207 XR_952208 XR_952941 XR_952942 XR_953003 XR_953004 XR_953077 XR_953078 NM_005510 NP_005501
Function Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:21750099}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:9799600}.

DOM3Z (B-12) - sc-393141 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DOM3Z (B-12): sc-393141. Western blot analysis of DOM3Z expression in non-transfected 293T: sc-117752 (A), human DOM3Z transfected 293T: sc-173189 (B), SH-SY5Y (C), Raji (D), MOLT-4 (E) and MCF7 (F) whole cell lysates.

DOM3Z (D-9) - sc-393167 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DOM3Z (D-9): sc-393167. Western blot analysis of DOM3Z expression in SH-SY5Y (A), MOLT-4 (B) and Raji (C) whole cell lysates and mouse testis (D) and human testis (E) tissue extracts.

DOM3Z (N-14) - sc-161033 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DOM3Z (N-14): sc-161033. Western blot analysis of DOM3Z expression in mouse testis tissue extract.

DOM3Z (G-14) - sc-161032 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DOM3Z (H-300) - sc-366756 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DOM3Z (H-300): sc-366756. Western blot analysis of DOM3Z expression in non-transfected: sc-117752 (A) and human DOM3Z transfected: sc-173189 (B) 293T whole cell lysates.

DOM3Z (T-13) - sc-161034 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DOM3Z (T-13): sc-161034. Western blot analysis of DOM3Z expression in NIH/3T3 nuclear extract (A) and MCF7 (B) and NIH/3T3 (C) whole cell lysates.

Anti-DOM3Z antibody - ab91407 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DOM3Z antibody (ab91407) at 1/50 dilution + MCF7 cell lysate at 35 µg

Anti-DXO / DOM3Z Antibody (aa85-134) - LS-C146417 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DOM3Z antibody LS-C146417 Western blot of Rat Liver lysate. Antibody concentration 1 ug/ml.

Anti-DXO / DOM3Z Antibody (aa35-84) - LS-C116440 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DOM3Z antibody LS-C116440 Western blot of COLO205 cell lysate.

Anti-DXO / DOM3Z Antibody (aa73-99) - LS-C99369 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of DOM3Z (arrow) using rabbit polyclonal DOM3Z Antibody (N-term Y88). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DOM3Z gene.

DOM3Z Antibody - NBP1-56979 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

DOM3Z Antibody - NBP1-33509 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DOM3Z Antibody [NBP1-33509] - Sample (30 ug of whole cell lysate) A: Molt-4 B: Raji 10% SDS PAGE, antibody diluted at 1:500.

DOM3Z Polyclonal Antibody - bs-9054R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DOM3Z antibody produced in rabbit - SAB2700463 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-DOM3Z: <B>Cat. No. SAB2700463</B>: Immunofluorescence analysis of methanol-fixed HeLa, using DOM3Z antibody at 1:200 dilution.

Anti-DOM3Z antibody produced in rabbit - HPA046708 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DOM3Z: <B>Cat. No. HPA046708</B>: Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.

Anti-DOM3Z, (N-terminal) antibody produced in rabbit - SAB2105801 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DOM3Z (N-Terminal): <B>Cat. No. SAB2105801</B>: DOM3Z in COLO205 cell lysates with DOM3Z antibody at 1.0 μg/mL.

ANTI-DOM3Z (N-TERM Y88) antibody produced in rabbit - SAB1303883 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DOM3Z (N-term Y88): <B>Cat. No. SAB1303883</B>: Western blot analysis of DOM3Z antibody (N-term Y88) in MCF-7 cell line lysates (35 μg/lane).

DOM3Z antibody - N-terminal region (ARP52085_P050) - ARP52085_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DOM3Z-Antibody-N-term-Y88 - AP6635a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of DOM3Z antibody (N-term Y88) (Cat. #AP6635a) in MCF-7 cell line lysates (35ug/lane). DOM3Z (arrow) was detected using the purified Pab.

DOM3Z Antibody - N-terminal region (OAAB03668) - OAAB03668 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

DOM3Z antibody [N1C1] - GTX112421 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-DOM3Z antibody [N1C1] used in ICC/IF. GTX112421

DOM3Z antibody - 70R-4475 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

DOM3Z antibody - 70R-16917 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

DOM3Z antibody - 11015-2-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded Breast cancer using 11015-2-AP(DOM3Z Antibody) at Dilution 1:50 (under 25x lens)

DOM3Z (N-term) antibody - AP17290PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of DOM3Z antibody (N-term Y88) (AP17290PU-N) in MCF-7 cell line lysates (35 µg/lane). DOM3Z (arrow) was detected using the purified Pab.
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