Gene Symbol | FKBP1B |
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Entrez Gene | 2281 |
Alt Symbol | FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase |
Species | Human |
Gene Type | protein-coding |
Description | FK506 binding protein 1B, 12.6 kDa |
Other Description | 12.6 kDa FK506-binding protein|12.6 kDa FKBP|FK506-binding protein 12.6|FK506-binding protein 1B|FKBP-12.6|FKBP-1B|PPIase FKBP1B|calstabin 2|h-FKBP-12|immunophilin FKBP12.6|peptidyl-prolyl cis-trans isomerase FKBP1B|rotamase |
Swissprots | Q9BQ40 P68106 Q53TM2 Q16645 Q13664 |
Accessions | AAY14663 BAE44300 CBF58189 CBU83624 EAX00768 EAX00769 EAX00770 P68106 AF322070 AAK11191 BC002614 AAH02614 BC050998 BF969580 D38037 BAA07232 L37086 AAC37581 S69800 AAB30685 S69815 AAB30684 XM_011532699 XP_011531001 NM_004116 NP_004107 NM_054033 NP_473374 |
Function | Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
Subcellular Location | Cytoplasm {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}. |
Tissue Specificity | Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus. {ECO:0000269|PubMed:10830164}. |
FKBP12.6 CRISPR/Cas9 KO Plasmid (h) - sc-401445 from Santa Cruz Biotechnology
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FKBP12.6 HDR Plasmid (h) - sc-401445-HDR from Santa Cruz Biotechnology
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FKBP12.6 Double Nickase Plasmid (h) - sc-401445-NIC from Santa Cruz Biotechnology
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FKBP12.6 Double Nickase Plasmid (h2) - sc-401445-NIC-2 from Santa Cruz Biotechnology
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FKBP12.6 CRISPR Activation Plasmid (h) - sc-401445-ACT from Santa Cruz Biotechnology
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FKBP12.6 CRISPR Activation Plasmid (h2) - sc-401445-ACT-2 from Santa Cruz Biotechnology
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FKBP12.6 Lentiviral Activation Particles (h) - sc-401445-LAC from Santa Cruz Biotechnology
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FKBP12.6 Lentiviral Activation Particles (h2) - sc-401445-LAC-2 from Santa Cruz Biotechnology
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FKBP12.6 siRNA (h) - sc-42891 from Santa Cruz Biotechnology
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FKBP12.6 shRNA Plasmid (h) - sc-42891-SH from Santa Cruz Biotechnology
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FKBP12.6 shRNA (h) Lentiviral Particles - sc-42891-V from Santa Cruz Biotechnology
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FKBP12.6 RNAi - H00002281-R02 from Novus Biologicals
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MISSION® esiRNA - EHU132441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8713 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8713 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05590 from Sigma-Aldrich
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FKBP1B siRNA (Human) - CRH1595 from Cohesion Biosciences
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FKBP12.6 RNAi - H00002281-R01 from Novus Biologicals
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FKBP1B - MBS8200653 from MyBioSource
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shRNA set against Human FKBP1B (NM_004116.3) - SHH295213 from Creative biogene
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Human FKBP1B siRNA - orb262097 from Biorbyt
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FKBP1B shRNA Plasmid (Human) - CHH1595 from Cohesion Biosciences
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FKBP1B miRNA 3'UTR clone - MiUTR3H-03524 from Creative biogene
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FKBP1B miRNA 3'UTR clone - MiUTR3H-03525 from Creative biogene
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