FLNC

Gene Symbol	FLNC
Entrez Gene	2318
Alt Symbol	ABP-280, ABP280A, ABPA, ABPL, FLN2, MFM5, MPD4
Species	Human
Gene Type	protein-coding
Description	filamin C, gamma
Other Description	ABP-280-like protein|ABP-L, gamma filamin|actin binding protein 280|filamin-2|filamin-C
Swissprots	Q9NYE5 Q07985 Q9UMR8 B2ZZ88 Q9Y503 Q14315 Q9NS12 O95303
Accessions	AAF67190 AAF68195 ACF49257 CAB51535 EAW83689 EAW83690 EAW83691 Q14315 AB208865 BAD92102 AB371585 BAG48314 AF089841 AAD12245 AF146692 AAF80245 AJ012737 CAB46442 AK001048 BAG50853 AK126540 F30928 X70083 CAA49688 X70084 CAA49689 NM_001127487 NP_001120959 NM_001458 NP_001449
Function	Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11038172}. Membrane {ECO:0000269|PubMed:11038172}; Peripheral membrane protein {ECO:0000269|PubMed:11038172}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11038172}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11038172}. Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Targeting to developing and mature Z lines is mediated by the intradomain insert.
Tissue Specificity	Highly expressed in striated muscles. Weakly expressed in thyroid, fetal brain, fetal lung, retina, spinal cord and bone marrow. Not expressed in testis, pancreas, adrenal gland, placenta, liver and kidney. {ECO:0000269|PubMed:11038172, ECO:0000269|PubMed:7689010, ECO:0000269|PubMed:9791010}.
Top Pathways	Focal adhesion, MAPK signaling pathway, Salmonella infection, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Filamin C protein fragment - ab158453 from Abcam Category Protein Source Wheat germ Species Human

ABP-280 / FLNC Antibody Blocking Peptide - LS-E23496 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FLNC Protein - H00002318-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human Filamin C Gamma Protein - abx066663 from Abbexa Category Protein Source E.coli Species Human

Human Filamin C Gamma Protein - abx066662 from Abbexa Category Protein Source E.coli Species Human

Filamin-C - H00002318-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Filamin-C - H00002318-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Filamin - 03-62006 from ARP American Research Products Category Protein Prices $329.00 Sizes 250 µg Source Chicken Gizzard

Filamin C Gamma (FLNC), Human - 20-9037 from ARP American Research Products Category Protein Prices $499.00 Sizes 50 µg Source E.coli Species Human

Recombinant Filamin C Gamma (FLNC) - RPE932Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Filamin C Gamma (FLNC) - RPE932Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Filamin C Gamma (FLNC) - RPE932Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Filamin C Gamma (FLNC) - RPE932Hu02 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Filamin-C(FLNC) ,partial - CSB-YP613498HU CSB-EP613498HU CSB-BP613498HU CSB-MP613498HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FLNC Protein - NBP1-89300PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

FLNC Peptide, Human - M34GP05781H from Creative Peptides Category Peptide Source Synthetic. Species Human

Filamin C Gamma, Recombinant Protein - MBS2030652 from MyBioSource Category Protein Prices $185.00, $385.00, $595.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Filamin C Gamma (FLNC), Recombinant Protein - MBS2011377 from MyBioSource Category Protein Prices $185.00, $385.00, $595.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Filamin-C (FLNC), partial, Recombinant Protein - MBS1438861 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

FLNC Recombinant Protein (OPCD03267) - OPCD03267 from Aviva Systems Biology Category Protein Source E.coli Species Human

FLNC Recombinant Protein (OPCD03268) - OPCD03268 from Aviva Systems Biology Category Protein Source E.coli Species Human

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