RAP1A

Gene Symbol RAP1A
Entrez Gene 5906
Alt Symbol C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21
Species Human
Gene Type protein-coding
Description RAP1A, member of RAS oncogene family
Other Description GTP-binding protein smg p21A|Ras-related protein Krev-1|ras-related protein Rap-1A
Swissprots P62834 P10113
Accessions CAA00804 EAW56503 P62834 AB051846 BAB61868 AB451235 BAG70049 AB451360 BAG70174 AF493912 AAM12626 AK023457 AK094737 AK293044 BAF85733 BC014086 AAH14086 BG743233 BI460853 BQ220294 BT019666 AAV38472 BU150941 BU167449 BU189979 BX473371 CA446565 CD108761 DA102623 DB312010 EU831467 ACE87154 EU831554 ACE86473 M22995 AAA36150 X12533 CAA31051 XM_011541883 XP_011540185 XR_946724 NM_001010935 NP_001010935 NM_001291896 NP_001278825 NM_002884 NP_002875
Function Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11359771}; Lipid-anchor {ECO:0000269|PubMed:11359771}. Cytoplasm {ECO:0000269|PubMed:11359771}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359771}. Cell junction {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.
Top Pathways Rap1 signaling pathway, Focal adhesion, cAMP signaling pathway, Pancreatic secretion, Chemokine signaling pathway

Active Rap1 Detection Kit - 8818 from Cell Signaling Technology

Category Cellular Assay
Prices $719.00
Sizes 1 kit (30 reactions)
Figure 1. NIH/3T3 cell lysates (500 µl at 1 mg/ml) were treated in vitro with GTPγS or GDP to activate or inactivate Rap1 (refer to optional step C in protocol). The lysates were then incubated with glutathione resin and GST-RalGDS-RBD (lanes 2 and 3). GTPγS-treated lysate was also incubated without GST-RalGDS-RBD in the presence of glutathione resin as a negative control (lane 4). Western blot analysis of cell lysate (20 µg, lane 1) or 20 µl of the eluted samples (lanes 2, 3, and 4) was performed using a Rap1 Rabbit Antibody. Anti-rabbit IgG, HRP-linked Antibody #7074 was used as the secondary antibody. Detection was performed using 1X LumiGLO ® reagent and peroxide (20X LumiGLO ® Reagent and 20X Peroxide #7003), followed by exposure to x-ray film.

Human RAP1A ELISA Kit (Sandwich ELISA) - LS-F12469 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.156
Range 0.156-10 ng/ml

Ras-related protein Rap-1A, RAP1A, Human, ELISA Kit - E3220h from ARP American Research Products

Category ELISA Kit
Prices $660.00
Sizes 96 t
Range 0.156-10 ng/mL

RAP1A, member of RAS oncogene family, ELISA Kit - MBS9336367 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1ng/ml.
Range 0.625ng/ml-20ng/ml.

Bovine RAP1A ELISA Kit (Custom ELISA) - LS-F19844 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Mouse RAP1A ELISA Kit (Custom ELISA) - LS-F19846 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Rat RAP1A ELISA Kit (Custom ELISA) - LS-F19845 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Human RAP1A(Ras-related protein Rap-1A) ELISA Kit - E-EL-H1990 from Iwai North America Inc.

Category ELISA Kit
Prices $580.00
Sizes 1 kit
Sensitivity 9.38 pg/mLpg/mL
Range 15.63~1000 pg/mL

Human RAP1A(Ras-related protein Rap-1A) ELISA Kit - E-EL-H1986 from Elabscience

Category ELISA Kit
Sensitivity 0.10 ng/mL
Range 0.16—10 ng/mL

Ras-related protein Rap-1A, RAP1A, Human, ELISA Kit - E-EL-H1986 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.094
Range 0.156-10ng/mL
Ras-related protein Rap-1A, RAP1A, Human, ELISA Kit

RAP1A - EKH4520 from Nordic BioSite

Sensitivity 0.094ng/ml
Range 0.156-10ng/ml

RAP1A ELISA Kit (Human) : 96 Wells (OKEH01696) - OKEH01696 from Aviva Systems Biology

Category ELISA Kit
Prices $450.00
Sizes 96 wells
Sensitivity < 0.056 ng/mL
Range 0.156 - 10 ng/mL

Human RAP1A ELISA Kit - E032930 from Biobool

Category ELISA Kit
Sensitivity <0.094ng/ml

Human Ras-related protein Rap-1A ELISA Kit - EK4577 from Signalway Antibody

Category ELISA Kit
Prices $659.00
Sizes 1x96t
Sensitivity less than 43pg/mL
Range 78-5000 pg/mL

Human PPIL1(Peptidylprolyl Isomerase/Cyclophilin Like 1) ELISA Kit - E-EL-H1986 from Iwai North America Inc.

Category ELISA Kit
Prices $580.00
Sizes 1 kit
Sensitivity 0.1 ng/mLng/mL
Range 0.16~10 ng/mL

Ras-Related Protein Rap-1A (RAP1A), ELISA Kit - MBS9348121 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ras-Related Protein Rap-1A (RAP1A), ELISA Kit - MBS9357595 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ras-Related Protein Rap-1A (RAP1A), ELISA Kit - MBS9345303 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ras-Related Protein Rap-1A (RAP1A), ELISA Kit - MBS9346314 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ras-Related Protein Rap-1A (RAP1A), ELISA Kit - MBS9362552 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ras-Related Protein Rap-1A (RAP1A), ELISA Kit - MBS9359283 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ras-Related Protein Rap-1A (RAP1A), ELISA Kit - MBS9360641 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ras-Related Protein Rap-1A (RAP1A), ELISA Kit - MBS9355514 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ras-Related Protein Rap-1A (RAP1A), ELISA Kit - MBS9349504 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ras-Related Protein Rap-1A (RAP1A), ELISA Kit - MBS9360368 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Search more