Gene Symbol | ACSBG1 |
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Entrez Gene | 23205 |
Alt Symbol | BG, BG1, BGM, GR-LACS, LPD |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA synthetase bubblegum family member 1 |
Other Description | bubblegum|lipidosin|long-chain-fatty-acid--CoA ligase ACSBG1|very long-chain acyl-CoA synthetase |
Swissprots | Q96GR2 Q9HC26 O75126 B2RB61 Q76N27 |
Accessions | CBF65091 CBU89962 EAW99180 Q96GR2 AF070624 AF179481 AAG09404 AK054882 BAG51439 AK294202 BAH11696 AK295269 BAH12022 AK299597 BAH13077 AK314508 BAG37108 BC009289 AAH09289 BC040252 DC401742 DQ896428 ABM87427 EU176436 ABW03887 XM_011521389 XP_011519691 XM_011521390 XP_011519692 XM_011521391 XP_011519693 NM_001199377 NP_001186306 NM_015162 NP_055977 |
Function | Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. {ECO:0000269|PubMed:10954726, ECO:0000269|PubMed:12975357}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10954726}. Cytoplasmic vesicle {ECO:0000250}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. |
Tissue Specificity | Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary. {ECO:0000269|PubMed:10954726, ECO:0000269|PubMed:12975357}. |
Top Pathways | Adipocytokine signaling pathway, PPAR signaling pathway, Fatty acid biosynthesis, Fatty acid degradation, Fatty acid metabolism |
ACSBG1 CRISPR/Cas9 KO Plasmid (h) - sc-408837 from Santa Cruz Biotechnology
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ACSBG1 HDR Plasmid (h) - sc-408837-HDR from Santa Cruz Biotechnology
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ACSBG1 Double Nickase Plasmid (h) - sc-408837-NIC from Santa Cruz Biotechnology
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ACSBG1 Double Nickase Plasmid (h2) - sc-408837-NIC-2 from Santa Cruz Biotechnology
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ACSBG1 CRISPR Activation Plasmid (h) - sc-408837-ACT from Santa Cruz Biotechnology
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ACSBG1 CRISPR Activation Plasmid (h2) - sc-408837-ACT-2 from Santa Cruz Biotechnology
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ACSBG1 Lentiviral Activation Particles (h) - sc-408837-LAC from Santa Cruz Biotechnology
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ACSBG1 Lentiviral Activation Particles (h2) - sc-408837-LAC-2 from Santa Cruz Biotechnology
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ACSBG1 siRNA (h) - sc-89919 from Santa Cruz Biotechnology
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ACSBG1 shRNA Plasmid (h) - sc-89919-SH from Santa Cruz Biotechnology
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ACSBG1 shRNA (h) Lentiviral Particles - sc-89919-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU055321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2748 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2748 from Sigma-Aldrich
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ACSBG1 siRNA (Human) - CRH8084 from Cohesion Biosciences
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ACSBG1 - MBS8225440 from MyBioSource
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shRNA set against Human ACSBG1 (NM_015162.4) - SHH230674 from Creative biogene
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Human ACSBG1 siRNA - orb268586 from Biorbyt
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ACSBG1 shRNA Plasmid (Human) - CHH8084 from Cohesion Biosciences
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ACSBG1 miRNA 3'UTR clone - MiUTR3H-13224 from Creative biogene
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