Gene Symbol | GFPT1 |
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Entrez Gene | 2673 |
Alt Symbol | CMSTA1, GFA, GFAT, GFAT 1, GFAT1, GFAT1m, GFPT, GFPT1L, MSLG |
Species | Human |
Gene Type | protein-coding |
Description | glutamine--fructose-6-phosphate transaminase 1 |
Other Description | D-fructose-6-phosphate amidotransferase 1|glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1|glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1|glutamine:fructose-6-phosphate amidotransferase 1|hexosephosphate aminotransferase 1 |
Swissprots | Q9BXF8 Q53QE6 Q06210 |
Accessions | AAY14827 EAW99851 EAW99852 EAW99853 Q06210 AF131846 AF334737 AAK15342 AF445027 AAL38588 AW079566 BC045641 AAH45641 BG723175 BI560595 BM744371 DB133199 M90516 AAA58502 NM_001244710 NP_001231639 NM_002056 NP_002047 |
Function | Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1. |
Tissue Specificity | Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle. {ECO:0000269|PubMed:11679416}. |
Top Pathways | Amino sugar and nucleotide sugar metabolism, Alanine, aspartate and glutamate metabolism |
GFAT1 CRISPR/Cas9 KO Plasmid (h) - sc-403022 from Santa Cruz Biotechnology
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GFAT1 HDR Plasmid (h) - sc-403022-HDR from Santa Cruz Biotechnology
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GFAT1 Double Nickase Plasmid (h) - sc-403022-NIC from Santa Cruz Biotechnology
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GFAT1 Double Nickase Plasmid (h2) - sc-403022-NIC-2 from Santa Cruz Biotechnology
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GFAT1 CRISPR Activation Plasmid (h) - sc-403022-ACT from Santa Cruz Biotechnology
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GFAT1 CRISPR Activation Plasmid (h2) - sc-403022-ACT-2 from Santa Cruz Biotechnology
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GFAT1 Lentiviral Activation Particles (h) - sc-403022-LAC from Santa Cruz Biotechnology
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GFAT1 Lentiviral Activation Particles (h2) - sc-403022-LAC-2 from Santa Cruz Biotechnology
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GFAT1 siRNA (h) - sc-60681 from Santa Cruz Biotechnology
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GFAT1 shRNA Plasmid (h) - sc-60681-SH from Santa Cruz Biotechnology
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GFAT1 shRNA (h) Lentiviral Particles - sc-60681-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU082891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9245 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9245 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07117 from Sigma-Aldrich
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GFPT1 siRNA (Human) - CRH1782 from Cohesion Biosciences
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GFPT1 - MBS8203867 from MyBioSource
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shRNA set against Human Gfpt1 (NM_002056.3) - SHH300650 from Creative biogene
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Human GFPT1 siRNA - orb262284 from Biorbyt
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GFPT1 shRNA Plasmid (Human) - CHH1782 from Cohesion Biosciences
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