| Gene Symbol |
PPAP2C
|
| Entrez Gene |
8612
|
| Alt Symbol |
LPP2, PAP-2c, PAP2-g
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidic acid phosphatase type 2C
|
| Other Description |
PAP2-gamma|PAP2c|lipid phosphate phosphohydrolase 2|phosphatidate phosphohydrolase type 2c|phosphatidic acid phosphatase 2c|phosphatidic acid phosphohydrolase type 2c|type-2 phosphatidic acid phosphatase-gamma
|
| Swissprots |
E9PAY8 A6NLV0 O43688
|
| Accessions |
EAW61207 EAW61208 EAW61209 O43688 AA428937 AB209696 BAD92933 AF035959 AAC15968 AF047760 AAC32104 AF056083 AAC25666 BC002806 AAH02806 BE615792 BG831889 BM050291 BM982485 BT007021 AAP35667 HY160303 XM_011528396 XP_011526698 NM_003712 NP_003703 NM_177526 NP_803545 NM_177543 NP_808211
|
| Function |
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Found mainly in brain, pancreas and placenta.
|
| Top Pathways |
Fc gamma R-mediated phagocytosis, Fat digestion and absorption, Choline metabolism in cancer, Ether lipid metabolism, Glycerolipid metabolism
|