| Gene Symbol | PPAP2C |
|---|---|
| Entrez Gene | 8612 |
| Alt Symbol | LPP2, PAP-2c, PAP2-g |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidic acid phosphatase type 2C |
| Other Description | PAP2-gamma|PAP2c|lipid phosphate phosphohydrolase 2|phosphatidate phosphohydrolase type 2c|phosphatidic acid phosphatase 2c|phosphatidic acid phosphohydrolase type 2c|type-2 phosphatidic acid phosphatase-gamma |
| Swissprots | E9PAY8 A6NLV0 O43688 |
| Accessions | EAW61207 EAW61208 EAW61209 O43688 AA428937 AB209696 BAD92933 AF035959 AAC15968 AF047760 AAC32104 AF056083 AAC25666 BC002806 AAH02806 BE615792 BG831889 BM050291 BM982485 BT007021 AAP35667 HY160303 XM_011528396 XP_011526698 NM_003712 NP_003703 NM_177526 NP_803545 NM_177543 NP_808211 |
| Function | Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Found mainly in brain, pancreas and placenta. |
| Top Pathways | Fc gamma R-mediated phagocytosis, Fat digestion and absorption, Choline metabolism in cancer, Ether lipid metabolism, Glycerolipid metabolism |