SHARPIN

Gene Symbol	SHARPIN
Entrez Gene	81858
Alt Symbol	SIPL1
Species	Human
Gene Type	protein-coding
Description	SHANK-associated RH domain interactor
Other Description	hSIPL1|shank-associated RH domain-interacting protein|shank-interacting protein-like 1|sharpin
Swissprots	Q9H0F6 Q8N2E7 A6NEG3 C0L3L2 Q8IXF5 D3DWL3 Q8TB25 Q8IXF6 Q9BUE4
Accessions	CAI72172 EAW82150 EAW82151 EAW82152 EAW82153 EAW82154 EAW82155 EAW82156 Q9H0F6 AB052764 BAC53797 AB052765 BAC53798 AK075518 BAC11666 AL136816 CAB66750 BC002688 AAH02688 BC017230 AAH17230 BC025244 AAH25244 BC034028 AAH34028 BE877614 BI911222 CN260986 DQ583527 FJ655995 ACN38058 NM_030974 NP_112236 NR_038270
Function	Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:20179993}. Cell junction, synapse {ECO:0000250}. Note=Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1. {ECO:0000250}.
Tissue Specificity	Highly expressed in skeletal muscle and placenta and at lower levels in brain, heart, colon without mucosa, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. Up-regulated in various tumor tissues such as kidney, liver, ovary and pancreas tumors. {ECO:0000269|PubMed:20179993}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Sharpin siRNA I - 12875 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SHARPIN CRISPR/Cas9 KO Plasmid (h) - sc-404836 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SHARPIN HDR Plasmid (h) - sc-404836-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SHARPIN Double Nickase Plasmid (h) - sc-404836-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SHARPIN Double Nickase Plasmid (h2) - sc-404836-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SHARPIN CRISPR Activation Plasmid (h) - sc-404836-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SHARPIN CRISPR Activation Plasmid (h2) - sc-404836-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SHARPIN Lentiviral Activation Particles (h) - sc-404836-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SHARPIN Lentiviral Activation Particles (h2) - sc-404836-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SHARPIN siRNA (h) - sc-77833 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SHARPIN shRNA Plasmid (h) - sc-77833-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SHARPIN shRNA (h) Lentiviral Particles - sc-77833-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SHARPIN RNAi - H00081858-R02 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU152211 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19287 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19287 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

SHARPIN siRNA (Human) - CRJ3071 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SHARPIN - MBS8223779 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SHARPIN CRISPR/Cas9 KO Plasmid (h2) - sc-404836-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SHARPIN HDR Plasmid (h2) - sc-404836-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human SHARPIN(NM_030974.3) - SHR223814 from Creative biogene Category siRNA Species Reactivities Human

Human SHARPIN siRNA - orb273572 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SHARPIN shRNA Plasmid (Human) - CHJ3071 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SHARPIN miRNA 3'UTR clone - MiUTR1H-09372 from Creative biogene Species Reactivities Human

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