| Gene Symbol | ATG12 |
|---|---|
| Entrez Gene | 9140 |
| Alt Symbol | APG12, APG12L, FBR93, HAPG12 |
| Species | Human |
| Gene Type | protein-coding |
| Description | autophagy related 12 |
| Other Description | ATG12 autophagy related 12 homolog|Apg12 (autophagy, yeast) homolog|ubiquitin-like protein ATG12 |
| Swissprots | O94817 Q6PJV2 |
| Accessions | EAW48954 EAW48955 EAW48956 O94817 AB002440 AB002449 AB017507 BAA36493 AK098251 AK313320 BAG36125 AL161968 BC011033 AAH11033 BC012266 AAH12266 BM697565 BP335591 BX327373 CB995198 CN400030 CR978239 DA005347 DB048378 DB530852 EU554057 ACD74941 NR_073604 NM_001277783 NP_001264712 NM_004707 NP_004698 NR_033362 NR_033363 NR_073603 |
| Function | Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. {ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:17999726, ECO:0000269|PubMed:19074260, ECO:0000269|PubMed:19164948, ECO:0000269|PubMed:19666601, ECO:0000269|PubMed:23202584}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000269|PubMed:22342342}; Peripheral membrane protein {ECO:0000269|PubMed:22342342}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:9852036}. |
| Top Pathways | RIG-I-like receptor signaling pathway, Regulation of autophagy |
Atg12 CRISPR/Cas9 KO Plasmid (h) - sc-401894 from Santa Cruz Biotechnology
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Atg12 HDR Plasmid (h) - sc-401894-HDR from Santa Cruz Biotechnology
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Atg12 Double Nickase Plasmid (h) - sc-401894-NIC from Santa Cruz Biotechnology
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Atg12 Double Nickase Plasmid (h2) - sc-401894-NIC-2 from Santa Cruz Biotechnology
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Atg12 CRISPR Activation Plasmid (h) - sc-401894-ACT from Santa Cruz Biotechnology
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Atg12 CRISPR Activation Plasmid (h2) - sc-401894-ACT-2 from Santa Cruz Biotechnology
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Atg12 Lentiviral Activation Particles (h) - sc-401894-LAC from Santa Cruz Biotechnology
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Atg12 Lentiviral Activation Particles (h2) - sc-401894-LAC-2 from Santa Cruz Biotechnology
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Atg12 siRNA (h) - sc-72578 from Santa Cruz Biotechnology
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Atg12 shRNA Plasmid (h) - sc-72578-SH from Santa Cruz Biotechnology
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Atg12 shRNA (h) Lentiviral Particles - sc-72578-V from Santa Cruz Biotechnology
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ATG12 RNAi - H00009140-R01 from Novus Biologicals
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MISSION® esiRNA - EHU036931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3643 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3643 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10051 from Sigma-Aldrich
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ATG12 siRNA (Human) - CRH6046 from Cohesion Biosciences
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ATG12 - MBS8202572 from MyBioSource
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shRNA set against Human ATG12 (NM_004707.3) - SHH242026 from Creative biogene
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Human ATG12 siRNA - orb266548 from Biorbyt
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ATG12 shRNA Plasmid (Human) - CHH6046 from Cohesion Biosciences
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ATG12 miRNA 3'UTR clone - MiUTR4H-TG00591 from Creative biogene
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