| Gene Symbol |
trp
|
| Entrez Gene |
43542
|
| Alt Symbol |
559, CG7875, DmTRP, Dmel\CG7875, TRP, Trp, dTRP, dTrp, gene B, idl-B
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential
|
| Other Description |
CG7875-PA|CG7875-PB|Cosens-Manning mutant|INAD localization-B|transient photreceptor potential|transient receptor potential protein|trp-PA|trp-PB
|
| Swissprots |
Q9VAE1 P19334 Q7YU76
|
| Accessions |
AAF56970 AGB96469 P19334 BT150384 AGW52194 NM_001276161 NP_001263090 NM_057420 NP_476768
|
| Function |
A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development. {ECO:0000269|PubMed:10366618, ECO:0000269|PubMed:10908615, ECO:0000269|PubMed:2482778, ECO:0000269|PubMed:2516726, ECO:0000269|PubMed:9930700}.
|
| Subcellular Location |
Cell membrane {ECO:0000305|PubMed:10995445, ECO:0000305|PubMed:2516726, ECO:0000305|PubMed:7751943, ECO:0000305|PubMed:9010208}; Multi-pass membrane protein {ECO:0000305|PubMed:10995445, ECO:0000305|PubMed:2516726, ECO:0000305|PubMed:7751943, ECO:0000305|PubMed:9010208}. Note=Localized on plasma membrane loops found at the base of the rhabdomere, in close proximity to the calcium stores.
|
| Tissue Specificity |
Expressed predominantly in the rhabdomeres of photoreceptor cells. Expressed in the third antennal segment and in the olfactory segment at approximately 70 hours after puparium formation during antennal development. {ECO:0000269|PubMed:10366618, ECO:0000269|PubMed:10632594, ECO:0000269|PubMed:10995445, ECO:0000269|PubMed:2516726}.
|
| Top Pathways |
Phototransduction - fly
|