ARRB1

Gene Symbol ARRB1
Entrez Gene 100009235
Alt Symbol -
Species Rabbit
Gene Type protein-coding
Description arrestin, beta 1
Other Description beta-arrestin-1
Swissprots Q95223
Accessions Q95223 U75838 AAC48753 XM_008263909 XP_008262131
Function Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors,
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Membrane, clathrin- coated pit {ECO:0000305}. Cell projection, pseudopodium {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). {ECO:0000250}.
Top Pathways MAPK signaling pathway, Endocytosis, Chemokine signaling pathway, Phototransduction, Morphine addiction

Beta-arrestin-1, ARRB1, Rabbit, ELISA Kit - E1993Rb from ARP American Research Products

Category ELISA Kit
Prices $915.00
Sizes 96 t

Rabbit ARRb1 ELISA Kit - RTA0351 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

arrestin, beta 1, ELISA Kit - MBS922403 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of rat ARRB1 is typically less than 7 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 28 pg/ml -1800 pg/ml.

Rabbit ARRBeta1 (Arrestin Beta 1) ELISA Kit - E-EL-RB1126 from Iwai North America Inc.

Category ELISA Kit
Prices $722.50
Sizes 1 kit
Sensitivity N/A

Rabbit ARRB1 ELISA Kit - E075791 from Biobool

Category ELISA Kit

Rabbit ARRb1 ELISA Kit - ERTA0351 from ABclonal

Category ELISA Kit
Prices $495.00
Sizes 96 t
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