SUV420H1

Gene Symbol	SUV420H1
Entrez Gene	51111
Alt Symbol	CGI-85, CGI85, KMT5B
Species	Human
Gene Type	protein-coding
Description	suppressor of variegation 4-20 homolog 1 (Drosophila)
Other Description	C630029K18Rik|histone-lysine N-methyltransferase SUV420H1|lysine N-methyltransferase 5B|su(var)4-20 homolog 1|suv4-20h1
Swissprots	Q4V775 Q9H022 Q4FZB7 Q9Y393 Q9BUL0 B7WNX7 Q9NXV3 Q3SX56 Q6P150 Q96E44 Q9H2K3
Accessions	EAW74697 EAW74698 EAW74699 EAW74700 EAW74701 Q4FZB7 AF151843 AAD34080 AF264782 AAG36937 AI659791 AK000046 BAA90905 AK025183 AK025461 AK026428 AK225203 AK299201 BAH12968 AK314336 AL512763 CAC21680 BC002522 AAH02522 BC012933 AAH12933 BC065287 AAH65287 BC087834 AAH87834 BC098121 AAH98121 BC099714 AAH99714 BC103498 AAI03499 BC104483 AAI04484 BC108304 BG697990 BM152996 BM719058 CR997801 XM_005274035 XP_005274092 XM_005274036 XP_005274093 XM_005274037 XP_005274094 XM_006718581 XP_006718644 XM_011545091 XP_011543393 XM_011545092 XP_011543394 XM_011545093 XP_011543395 XM_011545094 XP_011543396 NM_001300907 NP_001287836 NM_001300908 NP_001287837 NM_001300909 NP_001287838 NM_016028 NP_057112 NM_017635 NP_060105
Function	Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. {ECO:0000250, ECO:0000269|PubMed:23720823}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:23720823}. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SUV420H1 overexpression lysate - LY413635 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

SUV420H1 overexpression lysate - LY414238 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SUV420H1 293 Cell Lysate - 406575 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg Species Drosophila

SUV420h1 Overexpression Lysate (Native) - NBL1-16627 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

SUV420H1 Over-expression Lysate Product - GWB-D98AEC from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Panoply™ Human SUV420H1 Knockdown Stable Cell Line - CSC-DC015430 from Creative biogene Category Cell Line Species Human

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