| Gene Symbol |
DTX1
|
| Entrez Gene |
1840
|
| Alt Symbol |
hDx-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
deltex 1, E3 ubiquitin ligase
|
| Other Description |
E3 ubiquitin-protein ligase DTX1|deltex homolog 1|deltex1|hDTX1|protein deltex-1
|
| Swissprots |
O60630 Q86Y01 Q9BS04
|
| Accessions |
EAW98028 EAW98029 Q86Y01 AF053700 AAC06246 BC005816 AAH05816 BC008321 BC048216 AAH48216 XM_011538009 XP_011536311 NM_004416 NP_004407
|
| Function |
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
|
| Tissue Specificity |
Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells. {ECO:0000269|PubMed:12753744, ECO:0000269|PubMed:9590294}.
|
| Top Pathways |
Notch signaling pathway
|