| Gene Symbol |
LPAR1
|
| Entrez Gene |
281136
|
| Alt Symbol |
EDG2
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
lysophosphatidic acid receptor 1
|
| Other Description |
LPA receptor 1|LPA-1|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2|lysophosphatidic acid receptor Edg-2|rec1.3
|
| Swissprots |
Q28031
|
| Accessions |
DAA26493 Q28031 BC120114 BC147965 U48236 AAC48695 XM_005210509 XP_005210566 XM_005210511 XP_005210568 XM_005210512 XP_005210569 XM_005210513 XP_005210570 XM_010808241 XP_010806543 NM_174047 NP_776472
|
| Function |
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell surface {ECO:0000250}. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co- localizes with RALA in the endocytic vesicles. {ECO:0000250}.
|
| Top Pathways |
Gap junction, PI3K-Akt signaling pathway, Rap1 signaling pathway, Neuroactive ligand-receptor interaction
|