Ciita

Gene Symbol Ciita
Entrez Gene 12265
Alt Symbol C2ta, EG669998, Gm9475, Mhc2ta
Species Mouse
Gene Type protein-coding
Description class II transactivator
Other Description MHC class II transactivator
Swissprots O78036 O78109 Q9TPP1 P79621 Q31115 O46787
Accessions AAB92364 AAB92365 EDK97316 EDK97317 EDK97318 EDK97319 P79621 AF042158 AAC34366 AF042159 AAC34367 AF100709 AAF06838 AF100710 AAF06839 AI182240 AK040723 BAC30683 AK138822 BAE23789 AK143956 BAE25629 AK153609 BAE32115 AK155184 BAE33100 AK155311 BAE33182 AK163054 BAE37173 BC107330 AAI07331 BC107331 AAI07332 BC140358 AAI40359 BC148699 AAI48700 BE850370 U46562 AAB05004 U60653 AAB48859 XM_006521724 XP_006521787 XM_006521725 XP_006521788 XM_006521726 XP_006521789 XM_006521728 XP_006521791 XM_011245810 XP_011244112 NM_001243760 NP_001230689 NM_001243761 NP_001230690 NM_001302618 NP_001289547 NM_001302619 NP_001289548 NM_007575 NP_031601
Function Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription, the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: phosphorylates the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (By similarity). {
Subcellular Location Nucleus. Nucleus, PML body {ECO:0000250}. Note=Recruited to PML body by PML. {ECO:0000250}.
Tissue Specificity Isoform 1 is expressed at very high levels in dendritic cells, at very low levels in spleen and thymus and is not detected in other tissues. Isoform 2 is detected at high levels in spleen and tonsil as well as in a number of B-lymphocyte cell lines, and at very low levels in dendritic cells. {ECO:0000269|PubMed:9184229}.
Top Pathways Primary immunodeficiency, Toxoplasmosis, Influenza A, Tuberculosis, Antigen processing and presentation

CIITA CRISPR/Cas9 KO Plasmid (m) - sc-419390 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CIITA HDR Plasmid (m) - sc-419390-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CIITA Double Nickase Plasmid (m) - sc-419390-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CIITA Double Nickase Plasmid (m2) - sc-419390-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CIITA CRISPR Activation Plasmid (m) - sc-419390-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CIITA CRISPR Activation Plasmid (m2) - sc-419390-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CIITA Lentiviral Activation Particles (m) - sc-419390-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CIITA Lentiviral Activation Particles (m2) - sc-419390-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CIITA siRNA (m) - sc-37740 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CIITA shRNA Plasmid (m) - sc-37740-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CIITA shRNA (m) Lentiviral Particles - sc-37740-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN28770 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28770 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CIITA siRNA (Mouse) - CRM0439 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

CIITA - MBS8222821 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse CIITA (NM_007575.3) - SHH264089 from Creative biogene

Category siRNA
Species Reactivities Mouse

CIITA CRISPR/Cas9 KO Plasmid (m2) - sc-419390-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CIITA HDR Plasmid (m2) - sc-419390-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Mouse CIITA siRNA - orb279915 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

CIITA shRNA Plasmid (Mouse) - CHM0439 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
Search more