Gene Symbol | DCLRE1A |
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Entrez Gene | 9937 |
Alt Symbol | PSO2, SNM1, SNM1A |
Species | Human |
Gene Type | protein-coding |
Description | DNA cross-link repair 1A |
Other Description | DNA cross-link repair 1A protein|DNA-crosslink repair gene SNM1|SNM1 homolog A |
Swissprots | Q6PJP8 Q6P5Y3 Q14701 D3DRC1 Q6PKL4 |
Accessions | AAT09762 ABI49507 EAW49489 EAW49490 Q6PJP8 AK307187 BC013124 AAH13124 BC062582 AAH62582 D42045 BAA07646 DA456679 DB224073 H98725 XM_006718090 XP_006718153 XM_011540429 XP_011538731 NM_001271816 NP_001258745 NM_014881 NP_055696 |
Function | May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. {ECO:0000269|PubMed:15542852}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10848582, ECO:0000269|PubMed:12446782, ECO:0000269|PubMed:15572677}. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross- linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1. |
Tissue Specificity | Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:12446782}. |
SNM1A CRISPR/Cas9 KO Plasmid (h) - sc-411393 from Santa Cruz Biotechnology
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SNM1A HDR Plasmid (h) - sc-411393-HDR from Santa Cruz Biotechnology
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SNM1A Double Nickase Plasmid (h) - sc-411393-NIC from Santa Cruz Biotechnology
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SNM1A Double Nickase Plasmid (h2) - sc-411393-NIC-2 from Santa Cruz Biotechnology
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SNM1A CRISPR Activation Plasmid (h) - sc-411393-ACT from Santa Cruz Biotechnology
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SNM1A CRISPR Activation Plasmid (h2) - sc-411393-ACT-2 from Santa Cruz Biotechnology
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SNM1A Lentiviral Activation Particles (h) - sc-411393-LAC from Santa Cruz Biotechnology
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SNM1A Lentiviral Activation Particles (h2) - sc-411393-LAC-2 from Santa Cruz Biotechnology
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SNM1A siRNA (h) - sc-90489 from Santa Cruz Biotechnology
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SNM1A shRNA Plasmid (h) - sc-90489-SH from Santa Cruz Biotechnology
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SNM1A shRNA (h) Lentiviral Particles - sc-90489-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU102221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6991 from Sigma-Aldrich
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DCLRE1A siRNA (Human) - CRH6679 from Cohesion Biosciences
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DCLRE1A - MBS8212646 from MyBioSource
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shRNA set against Human DCLRE1A (NM_014881.3) - SHH275205 from Creative biogene
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Human DCLRE1A siRNA - orb267181 from Biorbyt
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DCLRE1A shRNA Plasmid (Human) - CHH6679 from Cohesion Biosciences
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DCLRE1A miRNA 3'UTR clone - MiUTR3H-10742 from Creative biogene
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