| Gene Symbol |
PELI1
|
| Entrez Gene |
57162
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pellino E3 ubiquitin protein ligase 1
|
| Other Description |
E3 ubiquitin-protein ligase pellino homolog 1|pellino homolog 1|pellino-1|pellino-related intracellular-signaling molecule|protein pellino homolog 1
|
| Swissprots |
Q9GZY5 Q96SM0 Q96FA3 Q9HCX0
|
| Accessions |
AAY24274 CAE84324 CAE84325 EAW99948 EAW99949 EAW99950 Q96FA3 AF086327 AF300987 AAG17451 AF302505 AAG15393 AJ278859 CAC04320 AK022261 AK026714 AK027668 BAB55280 AK312441 BAG35350 AY364257 AAQ76816 BC011419 AAH11419 BC050019 AAH50019 BC050533 BC063611 AAH63611 BM992606 BX649152 DA804964 HQ448508 ADQ32988 XM_005264437 XP_005264494 XM_011532993 XP_011531295 XM_011532994 XP_011531296 XM_011532995 XP_011531297 XM_011532996 XP_011531298 XM_011532997 XP_011531299 NM_020651 NP_065702
|
| Function |
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. {ECO:0000269|PubMed:12496252, ECO:0000269|PubMed:17675297}.
|