EBI3

Gene Symbol EBI3
Entrez Gene 10148
Alt Symbol IL-27B, IL27B
Species Human
Gene Type protein-coding
Description Epstein-Barr virus induced 3
Other Description EBV-induced gene 3 protein|Epstein-Barr virus induced gene 3|IL-27 subunit beta|IL27 subunit|IL35 subunit|cytokine receptor|epstein-Barr virus-induced gene 3 protein|interleukin-27 subunit beta
Swissprots O75269 A0N0N2 Q14213
Accessions AAC33488 ABK41923 CBX32665 CBX32666 EAW69244 EAW69245 Q14213 BC015364 AAH15364 BC046112 AAH46112 DQ891589 ABM82515 EU176581 ABW03382 L08187 AAA93193 XM_011527619 XP_011525921 NM_005755 NP_005746
Function Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. {ECO:0000269|PubMed:12121660}.
Subcellular Location Secreted.

Ebi3 (H-6) - sc-365342 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ebi3 (H-6): sc-365342. Western blot analysis of human full length human recombinant Ebi3 fusion protein.

Ebi3 (H-110) - sc-32868 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ebi3 (H-110): sc-32868. Western blot analysis of Ebi3 expression in I-11.15 whole cell lysate.

Ebi3 (E-20) - sc-26798 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Ebi3 (G-4) - sc-166158 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ebi3 (G-4): sc-166158. Western blot analysis of Ebi3 expression in non-transfected: sc-117752 (A) and mouse Ebi3 transfected: sc-119902 (B) 293T whole cell lysates.

Ebi3 (M-75) - sc-32869 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ebi3 (M-75): sc-32869. Western blot analysis of Ebi3 expression in non-transfected: sc-117752 (A) and mouse Ebi3 transfected: sc-119902 (B) 293T whole cell lysates.

Ebi3 (N-20) - sc-26797 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ebi3 (N-20): sc-26797. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of trophoblastic cells and membrane staining of endothelial cells.

Anti-EBI3 antibody - ab83896 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-EBI3 antibody (ab83896) at 2 µg/ml + Rat spleen tissue lysate at 15 µg

Anti-EBI3 antibody - ab194443 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-EBI3 antibody (ab194443) at 1/2500 dilution + EBI3 recombinant protein (immunizing peptide) at 0.2 µg

Anti-EBI3 antibody - ab72102 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EBI3 antibody (ab72102) at 2 µg/mlLane 1 : Jurkat cell lysateLane 2 : Jurkat cell lysate with immunizing peptide

Anti-EBI3 antibody [DNT27] - ab118500 from Abcam

Prices $387.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone DNT27
ab119500 at 10 &microg/ml staining EBI3 in Human Lyphoid-Dendritic Cells by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Anti-EBI3 antibody [EPR5747] - ab124694 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5747
All lanes : Anti-EBI3 antibody [EPR5747] (ab124694) at 1/5000 dilution (purified)Lane 1 : Mouse kidney tissue lysateLane 2 : Mouse spleen tissue lysateLysates/proteins at 10 µg per lane.SecondaryHRP anti-rabbit IgG, specific to the non-reduced form of IgG at 1/1000 dilution

Anti-EBI3 / IL-27B Antibody (aa153-181) - LS-C157700 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of EBI3 Antibody antibody pre-incubated without(lane 1) and with(lane 2) blocking peptide in 293 cell line lysate. EBI3 Antibody (arrow) was detected using the purified antibody.

Anti-EBI3 / IL-27B Antibody (aa129-229) - LS-C307349 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-EBI3 Antibody (aa77-229) - LS-C311906 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EBI3 / IL-27B Antibody (aa153-181) - LS-C321003 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EBI3 / IL-27B Antibody - LS-C343722 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EBI3 / IL-27B Antibody (aa21-229) - LS-C314301 from LifeSpan Bioscience

Prices $415.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Western blot of recombinant EBI3.

Anti-EBI3 / IL-27B Antibody (aa120-170) IHC-plus™ - LS-B7207 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-EBI3 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7207 dilution 1:100.

Anti-EBI3 Antibody (aa11-229) IHC-plus™ - LS-B11702 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-EBI3 Antibody (Internal, clone EPR5747) IHC-plus™ - LS-B9777 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5747
Anti-EBI3 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9777 dilution 1:50.

Anti-EBI3 / IL-27B Antibody (aa1-230) - LS-C36270 from LifeSpan Bioscience

Prices $495.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-EBI3 / IL-27B Antibody (aa167-179) - LS-C112731 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-EBI3 / IL-27B Antibody (aa107-156) - LS-C116205 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EBI3 antibody LS-C116205 Western blot of U937 cell lysate.

Anti-EBI3 / IL-27B Antibody (aa51-67) - LS-C148396 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EBI3 / IL-27B Antibody (C-Terminus) - LS-C82902 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of EBI3 in human spleen tissue with LS-C82902 at 2.5 µg/ml.
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