| Gene Symbol |
lpxL
|
| Entrez Gene |
946216
|
| Alt Symbol |
ECK1039, JW1041, htrB, waaM
|
| Species |
Escherichia coli
|
| Gene Type |
protein-coding
|
| Description |
lauryl-acyl carrier protein (ACP)-dependent acyltransferase
|
| Other Description |
-
|
| Swissprots |
P0ACV0
|
| Accessions |
AAC74138 NP_415572
|
| Function |
Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A). Has 10 fold selectivity for lauroyl-ACP over myristoyl-ACP. In vitro, can also catalyze a slow second acylation reaction leading to the formation of Kdo(2)-(dilauroyl)- lipid IV(A). {ECO:0000269|PubMed:18656959, ECO:0000269|PubMed:2203778, ECO:0000269|PubMed:8662613}.
|
| Subcellular Location |
Cell inner membrane {ECO:0000255|HAMAP- Rule:MF_01942, ECO:0000269|PubMed:1846149, ECO:0000269|PubMed:18656959, ECO:0000269|PubMed:8662613}; Single- pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01942}.
|
| Top Pathways |
Lipopolysaccharide biosynthesis
|