| Gene Symbol |
UBE2V2
|
| Entrez Gene |
7336
|
| Alt Symbol |
DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2 variant 2
|
| Other Description |
1 alpha,25-dihydroxyvitamin D3-inducible|DDVit 1|MMS2 homolog|enterocyte differentiation promoting factor|enterocyte differentiation-associated factor 1|enterocyte differentiation-associated factor EDAF-1|enterocyte differentiation-promoting factor 1|methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of|vitamin D3-inducible protein
|
| Swissprots |
Q15819
|
| Accessions |
AAY16979 EAW86687 EAW86688 EAW86689 EAW86690 Q15819 AF049140 AAC05381 AK094617 AK123928 AK313447 BAG36236 BC007051 AAH07051 BC016332 AAH16332 BC016710 AAH16710 BC028673 AAH28673 BC062418 AAH62418 BT006744 AAP35390 CR407628 CAG28556 DQ892507 ABM83433 DQ895721 ABM86647 EU176520 ABW03321 EU176662 ABW03463 EU176696 ABW03497 U62136 AAB04758 X98091 CAA66717 XM_005251300 XP_005251357 XM_011517583 XP_011515885 NM_003350 NP_003341
|
| Function |
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. {ECO:0000269|PubMed:10089880, ECO:0000269|PubMed:14562038, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:9705497}.
|
| Tissue Specificity |
Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues. {ECO:0000269|PubMed:9199207, ECO:0000269|PubMed:9705497}.
|