| Gene Symbol |
CCDC62
|
| Entrez Gene |
84660
|
| Alt Symbol |
CT109, ERAP75, TSP-NY
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coiled-coil domain containing 62
|
| Other Description |
aaa-protein|cancer/testis antigen 109|coiled-coil domain-containing protein 60|coiled-coil domain-containing protein 62|testis-specific protein TSP-NY
|
| Swissprots |
Q6ZVF2 Q9BYZ5 Q6P9F0 B3KUP3 Q86VJ0 A8K8V1
|
| Accessions |
EAW98344 EAW98345 Q6P9F0 AK097663 BAG53505 AK124633 BAC85909 AK292466 BAF85155 AW628007 AY009105 AAG49396 AY254201 AAP13075 BC060796 AAH60796 CD556476 DB458565 XM_006719643 XP_006719706 XM_006719644 XP_006719707 XM_011538856 XP_011537158 XM_011538857 XP_011537159 XM_011538858 XP_011537160 XM_011538859 XP_011537161 XR_944784 NM_032573 NM_201435 NP_958843 NR_027918
|
| Function |
Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. {ECO:0000269|PubMed:19126643}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19126643}. Nucleus {ECO:0000269|PubMed:19126643}. Note=Mainly nuclear.
|
| Tissue Specificity |
Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (PubMed:19126643). Not detected in prostate by RT-PCR (PubMed:19165854). Overexpressed in various cancers. {ECO:0000269|PubMed:19126643, ECO:0000269|PubMed:19165854, ECO:0000269|Ref.1, ECO:0000269|Ref.4}.
|
![Western Blot: CCDC62 Overexpression Lysate (Adult Normal) [NBP2-05997] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CCDC62.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10597_CCDC62%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05997-img0001.jpg)