| Gene Symbol | secM |
|---|---|
| Entrez Gene | 944831 |
| Alt Symbol | ECK0098, JW5007, srrA, yacA |
| Species | Escherichia coli |
| Gene Type | protein-coding |
| Description | regulator of secA translation |
| Other Description | - |
| Swissprots | P75641 P10409 P62395 |
| Accessions | AAC73208 NP_414639 |
| Function | Regulates secA expression by translational coupling of the secM secA operon. Ribosomes translating the C-terminal region of secM can disrupt an RNA repressor helix that normally blocks secA translation initiation, derepressing the expression of secA. Translational pausing of secM at Pro-166 under secretion-limiting conditions increases the duration of the disruption and thus increases secA expression. This is controlled by interaction of the secM signal peptide with secA and the translocon, possibly by secA pulling the paused secM out of the ribosome. The arrest sequence (150-FXXXXWIXXXXGIRAGP-166) is sufficient to cause arrest of unrelated proteins. Elongation arrest can be alleviated by mutations in the 23S rRNA or in ribosomal protein L22. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:1834634}. Periplasm {ECO:0000269|PubMed:1834634}. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease. |
| Top Pathways | Protein export, Bacterial secretion system |
Recombinant Escherichia coli Secretion monitor(secM) - CSB-YP351745ENV CSB-EP351745ENV CSB-BP351745ENV CSB-MP351745ENV from Cusabio
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Secretion monitor (secM), Recombinant Protein - MBS1027672 from MyBioSource
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