JAK1

Gene Symbol JAK1
Entrez Gene 3716
Alt Symbol JAK1A, JAK1B, JTK3
Species Human
Gene Type protein-coding
Description Janus kinase 1
Other Description tyrosine-protein kinase JAK1
Swissprots P23458 Q9UD26 Q59GQ2
Accessions CBG22571 EAX06547 EAX06548 P23458 AB209057 BAD92294 AB219242 BAE02826 AK128375 AK314257 BC009079 BC023604 AAH23604 BC062431 AAH62431 BC111401 AAI11402 BC132729 AAI32730 BX647675 BX648044 HQ628631 AER93381 M64174 AAA36527 XM_005270841 XP_005270898 XM_006710624 XP_006710687 XM_011541395 XP_011539697 NM_002227 NP_002218
Function Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. {ECO:0000269|PubMed:11909529}.
Subcellular Location Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
Tissue Specificity Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. {ECO:0000269|PubMed:7896447}.
Top Pathways Viral carcinogenesis, Pancreatic cancer, Signaling pathways regulating pluripotency of stem cells, Osteoclast differentiation, Epstein-Barr virus infection

Phospho-Jak1 (Tyr1022/1023) Antibody - 3331 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT-29 cells treated with IL-4 (100 ng/ml) for the indicated times, using Phospho-Jak1 (Tyr1022/1023) Antibody (upper) or Jak1 Antibody (lower).

Jak1 (6G4) Rabbit mAb - 3344 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 6G4
Western blot analysis of extracts from ACHN, SR, CTLL-2 and PC12 cell lines using Jak1 (6G4) Rabbit mAb.

Jak1 Antibody - 3332 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from CTLL-2 and BaF3 cells, using Jak1 Antibody.

JAK1 (B-3) - sc-376996 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
JAK1 (B-3): sc-376996. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

JAK1 (A-9) - sc-1677 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
JAK1 (A-9): sc-1677. Immunofluorescence staining of methanol-fixed Jurkat cells showing membrane localization.

JAK1 (H-106) - sc-7228 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
JAK1 (H-106): sc-7228. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil tissue showing cytoplasmic and membrane staining.

JAK1 (HR-785) - sc-277 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
JAK1 (HR-785): sc-277. Western blot analysis of JAK1 expression in A-431 (A) and NIH/3T3 (B) whole cell lysates.

JAK1 (N-18) - sc-34477 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

JAK1 (Q-19) - sc-295 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
JAK1 (Q-19): sc-295. Western blot analysis of JAK1 expression in Jurkat whole cell lysate.

JAK1 (T-19) - sc-34478 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

JAK1 (73) - sc-136225 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
JAK1 (73): sc-136225. Western blot analysis of JAK1 expression in Jurkat whole cell lysate.

p-JAK1 (Tyr 1022/Tyr 1023) - sc-16773 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of JAK1 phosphorylation in untreated (A), mouse LIF (sc-4989) treated (B) and LIF and lambda protein phosphatase (sc-200312A) treated (C) 3T3-L1 whole cell lysates. Antibody tested: p-JAK1 (Tyr 1034/Tyr 1035)-R: sc-16773-R (A,B,C).

p-JAK1 (Tyr 1022) - sc-101716 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-JAK1 (Tyr 1022): sc-101716. Western blot analysis of phosphorylated JAK1 expression in cancerous thyroid tissue extract (A-D).

Anti-JAK1 (phospho Y1022 + Y1023) antibody [EPR1899(2)] - ab138005 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1899(2)
All lanes : Anti-JAK1 (phospho Y1022 + Y1023) antibody [EPR1899(2)] (ab138005) at 1/1000 dilutionLane 1 : Ramos cell lysates Lane 2 : Ramos cell lysates, treated with pervanadateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-JAK1 antibody - ab125051 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-JAK1 antibody (ab125051) at 1 µg/ml + PC12 (Rat adrenal pheochromocytoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-JAK1 antibody - ab47435 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of paraffin embedded human breast carcinoma tissue using ab47435 at dilution of 1/50-1/100. Right panel treated with peptide and left panel untreated

Anti-JAK1 antibody - ab14044 from Abcam

Prices $370.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-JAK1 antibody [EPR349(N)] - ab133666 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR349(N)
All lanes : Anti-JAK1 antibody [EPR349(N)] (ab133666) at 1/1000 dilutionLane 1 : Ramos cell lysateLane 2 : HT-29 cell lysateLane 3 : HeLa cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-JAK1 antibody [MM0783-33N17] - ab201661 from Abcam

Prices $359.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone MM0783-33N17

Jak1 Antibody (413104) [Unconjugated] - MAB4260 from Novus Biologicals

Prices $99.00, $259.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 413104

Jak1 [p Tyr1022] Antibody - NB100-82005 from Novus Biologicals

Prices $299.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western Blot: JAK1 [p Tyr1022] Antibody [NB100-82005] - Analysis of extracts from HT29 cells untreated or treated with UV using JAK1 [p Tyr1022] antibody.

Jak1 Antibody - NB100-82004 from Novus Biologicals

Prices $309.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: JAK1 Antibody [NB100-82004] - Analysis of extracts from 3T3, HepG2, HT29 and MDA cells using JAK1(Ab-1022) antibody

Jak1 Antibody (452804) - MAB42601 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 452804

Jak1 [p Tyr1022, p Tyr1023] Antibody - AF4510 from Novus Biologicals

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot shows lysates of Daudi human Burkitt's lymphoma cell line untreated (-) or treated (+) with 500 U/mL Recombinant Human IFN-a2A (Catalog # 11100-1) 15 minutes, or 100 ng/mL Recombinant Human IFN-? (Catalog # 285-IF) for 15 minutes. PVDF membrane was probed with 1 µg/mL Rabbit Anti-Human Phospho-Jak1 (Y1022/Y1023) Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4510) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band for Phospho-Jak1 (Y1022/Y1023) was detected at approximately 130 kDa (as indicated). For additional reference, duplicate lysates were probed with 1.0 µg/mL Human/Mouse/Rat Jak1 Mono­clonal Antibody (lower panel, Catalog # MAB4260). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 3.

Jak1 Antibody - NBP1-31815 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Jak1 Antibody [NBP1-31815] - JAK1 antibody detects JAK1 protein analysis A. 30 ug GL261 whole cell lysate/extract B. 30 ug C8D30 whole cell lysate/extract C. 30 ug NIH-3T3 whole cell lysate/extract D. 30 ug BCL-1 whole cell lysate/extract E. 30 ug Raw264.7 whole cell lysate/extract 5 % SDS-PAGE JAK1 antibody dilution: 1:1000
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