CHST2
| Gene Symbol | CHST2 |
|---|---|
| Entrez Gene | 9435 |
| Alt Symbol | C6ST, GST-2, GST2, Gn6ST-1, HEL-S-75, glcNAc6ST-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 |
| Other Description | N-acetylglucosamine 6-O-sulfotransferase 1|carbohydrate (chondroitin 6/keratan) sulfotransferase 2|carbohydrate sulfotransferase 2|epididymis secretory protein Li 75|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2 |
| Swissprots | Q9UED5 Q2M370 Q9Y4C5 D3DNG5 Q9Y6F2 Q9GZN5 |
| Accessions | BAB16887 EAW78952 EAW78953 Q9Y4C5 AB014679 BAA34265 AB014680 BAA34266 AB021124 BAB16886 AF083066 AAD20981 AK023268 BAG51179 BC017499 BC036930 BC042160 BC068604 BC105010 AAI05011 BC105012 AAI05013 BX387933 CA431595 EU668328 ACF94481 EU832159 ACE87509 EU832253 ACE86823 NM_004267 NP_004258 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. {ECO:0000269|PubMed:11042394}. |
| Subcellular Location | Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:22260995}; Single-pass type II membrane protein {ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:22260995}. |
| Tissue Specificity | Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes. {ECO:0000269|PubMed:10049591, ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:9722682}. |
| Top Pathways | Glycosaminoglycan biosynthesis - keratan sulfate |
CHST2 (C-18) - sc-68019 from Santa Cruz Biotechnology
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Anti-CHST2 antibody - ab127526 from Abcam
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Anti-CHST2 antibody - ab194565 from Abcam
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Anti-CHST2 antibody - ab84354 from Abcam
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Anti-CHST2 antibody - ab106996 from Abcam
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Anti-CHST2 antibody - ab136029 from Abcam
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Anti-CHST2 Antibody (aa493-522, APC) - LS-C208438 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa76-530) - LS-C125247 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa493-522, AP) - LS-C208439 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa493-522, Biotin) - LS-C208441 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa493-522, FITC) - LS-C208442 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa493-522, PE) - LS-C208444 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa493-522, Azide-free, HRP) - LS-C208443 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa312-339, AP) - LS-C208445 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa230-279) - LS-C145213 from LifeSpan Bioscience
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Anti-CHST2 Antibody (C-Terminus) - LS-C102229 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa312-339, APC) - LS-C208446 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa1-50) - LS-C119804 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa312-339, FITC) - LS-C208448 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa312-339, Biotin) - LS-C208447 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa312-339, Azide-free, HRP) - LS-C208449 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa312-339, PE) - LS-C208450 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa493-522) - LS-C320381 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa42-91) - LS-C291798 from LifeSpan Bioscience
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Anti-CHST2 Antibody (aa312-339) - LS-C320382 from LifeSpan Bioscience
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