APIP

Gene Symbol APIP
Entrez Gene 51074
Alt Symbol APIP2, CGI-29, CGI29, MMRP19, hAPIP
Species Human
Gene Type protein-coding
Description APAF1 interacting protein
Other Description APAF1-interacting protein|MTRu-1-P dehydratase|methylthioribulose-1-phosphate dehydratase|probable methylthioribulose-1-phosphate dehydratase
Swissprots A8K9D3 Q96HK2 Q6PJX6 Q8WVU2 Q9Y318 Q96GX9
Accessions EAW68161 Q96GX9 AF088034 AF132963 AAD27738 AK225249 AK226157 AK292648 BAF85337 AK302225 BAG63579 BC008440 AAH08440 BC009077 AAH09077 BC017594 AAH17594 BP200131 DA729016 HQ448158 ADQ32639 XM_011520154 XP_011518456 XM_011520155 XP_011518457 NM_015957 NP_057041
Function Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:22837397, ECO:0000269|PubMed:23285211}.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
Tissue Specificity Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney. {ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
Top Pathways Cysteine and methionine metabolism

APIP-Over-expression-Lysate - LY13157a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag APIP (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the APIP gene

APIP overexpression lysate - LY414309 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

APIP 293 Cell Lysate - 406896 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

APIP Overexpression Lysate (Native) - NBL1-07603 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: APIP Overexpression Lysate (Adult Normal) [NBL1-07603] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for APIP.

APIP (h): 293 Lysate - sc-111191 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

APIP Over-expression Lysate Product - GWB-9C41F0 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human APIP Knockdown Stable Cell Line - CSC-DC000756 from Creative biogene

Category Cell Line
Species Human
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