Casp9
| Gene Symbol | Casp9 |
|---|---|
| Entrez Gene | 12371 |
| Alt Symbol | AI115399, APAF-3, AW493809, CASP-9, Caspase-9, ICE-LAP6, Mch6 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | caspase 9 |
| Other Description | ICE-like apoptotic protease 6|apoptotic protease Mch-6|apoptotic protease-activating factor 3|caspase-9 |
| Swissprots | Q8C3Q9 |
| Accessions | EDL13398 EDL13399 Q8C3Q9 AB019600 BAA86895 AB019601 BAA86896 AK085095 BAC39365 AK085152 BAC39378 AK085561 AK154495 AK156500 BAE33734 AK162863 BAE37089 AK203861 BC056372 AAH56372 BC056447 AAH56447 BY549141 CT010400 CAJ18606 NM_001277932 NP_001264861 NM_015733 NP_056548 |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP) (By similarity). {ECO:0000250}. |
| Top Pathways | p53 signaling pathway, VEGF signaling pathway, PI3K-Akt signaling pathway, Small cell lung cancer, Non-small cell lung cancer |
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