| Gene Symbol | MOCS3 |
|---|---|
| Entrez Gene | 100124378 |
| Alt Symbol | UBA4 |
| Species | Pig |
| Gene Type | protein-coding |
| Description | molybdenum cofactor synthesis 3 |
| Other Description | Molybdenum cofactor synthesis protein 3|adenylyltransferase and sulfurtransferase MOCS3|molybdenum cofactor synthesis protein 3 |
| Swissprots | A5GFZ6 |
| Accessions | A5GFZ6 CAN13125 NM_001101819 NP_001095289 |
| Function | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. {ECO:0000255|HAMAP-Rule:MF_03049}. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03049}. |
| Top Pathways | Sulfur relay system |
Recombinant Pig Adenylyltransferase and sulfurtransferase MOCS3(MOCS3) - CSB-YP014707PI CSB-EP014707PI CSB-BP014707PI CSB-MP014707PI from Cusabio
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Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3) - MBS1121006 from MyBioSource
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