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Neutrophil Elastase/ELA2 Native Protein

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Summary
Product Discontinued
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    • Catalog Number
      NBP1-99633
    • Availability
      Product Discontinued

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Neutrophil Elastase/ELA2 Native Protein Summary

Description
Native Elastase

Source:Human Neutrophil
Amino Acid Sequence:(P08246)
Source
Human neutrophil
Protein/Peptide Type
Native Protein
Gene
ELANE
Purity
>95%, by SDS-PAGE

Applications/Dilutions

Dilutions
  • Bioactivity
  • SDS-Page
Application Notes
Specific activity: 20-22 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one micromole of Meo-Suc-Ala-Pro-Val-pNA per minute at 25C in 100 mM Tris-HCl, pH 7.5, with 500 mM NaCl.
Theoretical MW
29.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Buffer
Salt-free lyophilized solid.
Concentration
Lyoph
Purity
>95%, by SDS-PAGE
Reconstitution Instructions
Reconstitute with deionized H2O.

Alternate Names for Neutrophil Elastase/ELA2 Native Protein

  • Bone marrow serine protease
  • EC 3.4.21
  • EC 3.4.21.37
  • ELA2
  • ELA2granulocyte-derived elastase
  • ELANE
  • elastase 2, neutrophil
  • elastase, neutrophil expressed
  • Elastase-2
  • GE
  • HLEelastase-2
  • HNE
  • Human leukocyte elastase
  • Leukocyte Elastase
  • Medullasin
  • NE
  • Neutrophil Elastase
  • PMN elastase
  • PMN-E
  • polymorphonuclear elastase
  • SCN1

Background

Elastase, like trypsin and chymotrypsin, is a serine protease that also hydrolyses amides and esters. It is produced in the pancreas as an inactive zymogen, proelastase, and activated in the duodenum by trypsin. Elastase is distinctive in that it acts upon elastin.This enzyme degrades elastin, collagen, and proteoglycan and has been implicated in the development of pulmonary emphesema and rheumatoid arthritis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol ELANE