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Key Documents

PLA0234

Sigma-Aldrich

Rabbit anti-BCR Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

ALL, BCR/FGFR1 chimera protein, BCR1, CML, D22S11, D22S662, FGFR1/BCR chimera protein, PHL, breakpoint cluster region, renal carcinoma antigen NY-REN-26

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

technique(s)

flow cytometry: 0.5 μg
immunofluorescence: 1:500- 1:2,000
immunoprecipitation (IP): 10 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_004318.3

UniProt accession no.

P11274

shipped in

wet ice

Immunogen

The epitope recognized by PLA0234 maps to a region between residue 1221 and 1271 of human breakpoint cluster region using the numbering given in entry NP_004318.3 (GeneID 613).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

BCR (breakpoint cluster region) was identified as part of a fusion protein that results from a reciprocal translocation with the ABL gene between chromosomes 22 and 9. The BCR-ABL fusion is the cause of chronic myeloid leukemia (CML). The BCR protein contains a C2 domain, a DBL-homology domain, a PH domain, and a Rho-GAP domain and functions as a GTPase-activating protein for RAC1 and CDC42.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
1

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Wan Ru Lee et al.
PloS one, 10(4), e0124494-e0124494 (2015-04-18)
Scavenger receptor class B, type I (SR-BI) and its adaptor protein PDZK1 mediate responses to HDL cholesterol in endothelium. Whether the receptor-adaptor protein tandem serves functions in other vascular cell types is unknown. The current work determined the roles of

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