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Key Documents

PLA0110

Sigma-Aldrich

Rabbit anti-LATS2 Antibody, Affinity Purified

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

mouse, human

technique(s)

immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:1,000- 1:5,000

accession no.

NP_055387.1

UniProt accession no.

Q9NRM7

shipped in

wet ice

Immunogen

The epitope recognized by PLA0110 maps to a region between residues 1 and 50 of human Large Tumor Suppressor 2 using the numbering given in entry NP_055387.1 (GeneID 26524).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

LATS2 (Large Tumor Suppressor homolog 2) has been identified as a tumor suppressor protein and is a member of the Dbf2-related (NDR) family of protein kinases that are key components of the mitotic exit network. LATS2 appears to negatively regulate G2/M transitioning by down-regulating CDC2 kinase activity. LATS2 has also been identified as a negative regulator of the androgen receptor (AR) and may play a role in AR-mediated transcription and the development of prostate cancer.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
3

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Masahiro Tsujiura et al.
PloS one, 9(6), e100974-e100974 (2014-06-28)
Yes-associated protein (YAP) is a transcriptional co-activator and regulates cell proliferation and apoptosis. We investigated the clinical and biological significance of YAP in endometrial cancer (EMCA). YAP expression in 150 primary tumor tissues from patients with EMCA was evaluated by

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