XRCC3 Antibody (D-7): sc-271714
- XRCC3 Antibody (D-7) is a mouse monoclonal IgG2a κ XRCC3 antibody, cited in 9 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of XRCC3 of human origin
- XRCC3 Antibody (D-7) is recommended for detection of XRCC3 of human origin by WB, IP, IF and ELISA
- Anti-XRCC3 Antibody (D-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of XRCC3 (D-7): sc-271714.
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for XRCC3 Antibody (D-7) for WB applications. These reagents are now offered in bundles with XRCC3 Antibody (D-7) (see ordering information below).
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XRCC3 Antibody (D-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects XRCC3 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). XRCC3 (D-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. XRCC3 protein plays a crucial role in DNA repair processes, specifically in maintaining chromosome stability during cell division. XRCC3 is essential for repairing DNA double-strand breaks through homologous recombination, a process that ensures genetic integrity and prevents genomic instability, which can lead to cancer and other diseases. XRCC3 interacts directly with Rad51, a key protein in homologous recombination repair pathway, facilitating accurate repair of damaged DNA. This interaction is vital for proper functioning of DNA repair machinery, as any defects in XRCC3 or associated proteins can compromise cellular ability to repair DNA, ultimately affecting cell survival and proliferation. Anti-XRCC3 antibody (D-7) enables researchers to gain insights into mechanisms of DNA repair and implications of genetic stability in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
XRCC3 Antibody (D-7) References:
- DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity. | Modesti, M., et al. 1999. EMBO J. 18: 2008-18. PMID: 10202163
- The role of homologous recombination processes in the repair of severe forms of DNA damage in mammalian cells. | Thacker, J. 1999. Biochimie. 81: 77-85. PMID: 10214913
- A surfeit of RAD51-like genes? | Thacker, J. 1999. Trends Genet. 15: 166-8. PMID: 10322480
- Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. | Johnson, RD., et al. 1999. Nature. 401: 397-9. PMID: 10517641
- XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. | Pierce, AJ., et al. 1999. Genes Dev. 13: 2633-8. PMID: 10541549
- A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p. | Moshous, D., et al. 2000. Hum Mol Genet. 9: 583-8. PMID: 10699181
- XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. | Manuguerra, M., et al. 2006. Am J Epidemiol. 164: 297-302. PMID: 16707649
- XRCC3 depletion induces spontaneous DNA breaks and p53-dependent cell death. | Loignon, M., et al. 2007. Cell Cycle. 6: 606-11. PMID: 17351336
- XRCC3 polymorphism is associated with hypertension-induced left ventricular hypertrophy. | Ariyandy, A., et al. 2018. Hypertens Res. 41: 426-434. PMID: 29626209
- XRCC3 and NBS1 gene polymorphisms modulate the risk of pre-oral cancer and oral cancer in the North Indian population. | Nigam, K., et al. 2023. J Cancer Res Ther. 19: 304-311. PMID: 37006067
- XRCC1 protein interacts with one of two distinct forms of DNA ligase III. | Nash, RA., et al. 1997. Biochemistry. 36: 5207-11. PMID: 9136882
- XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. | Liu, N., et al. 1998. Mol Cell. 1: 783-93. PMID: 9660962
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
XRCC3 Antibody (D-7) | sc-271714 | 200 µg/ml | $316.00 | |||
XRCC3 Antibody (D-7): m-IgGκ BP-HRP Bundle | sc-522037 | 200 µg Ab, 40 µg BP | $354.00 | |||
XRCC3 Antibody (D-7): m-IgG2a BP-HRP Bundle | sc-546104 | 200 µg Ab; 10 µg BP | $354.00 | |||
XRCC3 Antibody (D-7) AC | sc-271714 AC | 500 µg/ml, 25% agarose | $416.00 | |||
XRCC3 Antibody (D-7) HRP | sc-271714 HRP | 200 µg/ml | $316.00 | |||
XRCC3 Antibody (D-7) FITC | sc-271714 FITC | 200 µg/ml | $330.00 | |||
XRCC3 Antibody (D-7) PE | sc-271714 PE | 200 µg/ml | $343.00 | |||
XRCC3 Antibody (D-7) Alexa Fluor® 488 | sc-271714 AF488 | 200 µg/ml | $357.00 | |||
XRCC3 Antibody (D-7) Alexa Fluor® 546 | sc-271714 AF546 | 200 µg/ml | $357.00 | |||
XRCC3 Antibody (D-7) Alexa Fluor® 594 | sc-271714 AF594 | 200 µg/ml | $357.00 | |||
XRCC3 Antibody (D-7) Alexa Fluor® 647 | sc-271714 AF647 | 200 µg/ml | $357.00 | |||
XRCC3 Antibody (D-7) Alexa Fluor® 680 | sc-271714 AF680 | 200 µg/ml | $357.00 | |||
XRCC3 Antibody (D-7) Alexa Fluor® 790 | sc-271714 AF790 | 200 µg/ml | $357.00 |