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Cytokeratin 7/17 Antibody (C46): sc-8421

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Datasheets
  • Cytokeratin 7/17 Antibody (C46) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
  • raised against a Cytoskeleton preparation from HeLa cells
  • recommended for detection of Cytokeratin 7 and Cytokeratin 17 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
  • See Cytokeratin 7 (RCK105): sc-23876 for Cytokeratin 7/17 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cytokeratin 7/17 Antibody (C46) for WB and IHC(P) applications. These reagents are now offered in bundles with Cytokeratin 7/17 Antibody (C46) (see ordering information below).

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SEE ALSO...

Cytokeratin 7/17 (also designated KRT7 antibody, Keratin 7 antibody, KRT17 antibody, Keratin 17 antibody) comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are expressed highly in a subset of squamous cell carcinomas while cytokeratin 18 is expressed in a majority of adenocarcinomas and basal cell carcinomas. Cytokeratin 7 is expressed in pancreatic duct cells and islets of Langerhans and is a marker for pancreatic duct cell differentiation. Cytokeratin 17 is normally expressed in complex epithelia basal cells and can be used as a marker for basal cell differentiation.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cytokeratin 7/17 Antibody (C46)

sc-8421
200 µg/ml
$316.00

Cytokeratin 7/17 Antibody (C46): m-IgG Fc BP-HRP Bundle

sc-536563
200 µg Ab; 10 µg BP
$354.00

Cytokeratin 7/17 Antibody (C46): m-IgGκ BP-HRP Bundle

sc-533714
200 µg Ab; 40 µg BP
$354.00

Cytokeratin 7/17 Antibody (C46): m-IgG1 BP-HRP Bundle

sc-544677
200 µg Ab; 20 µg BP
$354.00

What is the recommended fixation method for immunofluorescence staining with Cytokeratin 7/17 (C46): sc-8421 monoclonal antibody?

Asked by: Randy McDonald
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-25
  • y_2025, m_1, d_14, h_4CST
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Rated 4 out of 5 by from Good Western blot data in AGood Western blot data in A-431 and ME-180 whole cell lysates. -SCBT QC
Date published: 2015-04-11
Rated 5 out of 5 by from Great data with immunoGreat data with immuno-peroxidase staining of formalin-fixed, paraffin-embedded human liver tumor samples. -SCBT QC
Date published: 2015-02-07
Rated 5 out of 5 by from Good IF data obtained in HeLa samplesGood IF data obtained in HeLa samples. -SCBT QC
Date published: 2015-01-26
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Cytokeratin 7/17 Antibody (C46) is rated 4.7 out of 5 by 3.
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