γ-catenin Antibody (F-2): sc-514116

γ-catenin Antibody (F-2) is a mouse monoclonal IgG1 antibody that detects γ-catenin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). γ-catenin, also known as plakoglobin, is a crucial component of the catenin/cadherin complex, which plays a vital role in cellular adhesion and signaling pathways. γ-catenin is primarily located in the cytoplasm and at the cell membrane, where γ-catenin interacts with cadherins, such as E-cadherin and N-cadherin, facilitating the formation of adherens junctions that are essential for maintaining tissue integrity and cellular communication. Proper localization of γ-catenin ensures effective cell-cell adhesion, which is critical for processes such as embryonic development, tissue repair, and maintenance of epithelial architecture. Dysregulation of γ-catenin has been implicated in various diseases, including cancer, where altered adhesion properties can lead to increased cell migration and metastasis. anti-γ-catenin antibody (F-2) is an invaluable tool for researchers studying the dynamics of cell adhesion and molecular mechanisms underlying cellular interactions in health and disease.

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γ-catenin Antibody (F-2) References:

1. Alterations of beta- and gamma-catenin in N-butyl-N-(-4-hydroxybutyl)nitrosamine-induced murine bladder cancer.  |  Shiina, H., et al. 2001. Cancer Res. 61: 7101-9. PMID: 11585741
2. Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line.  |  Maeda, O., et al. 2004. Oncogene. 23: 964-72. PMID: 14661054
3. Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.  |  Zheng, X., et al. 2004. Blood. 103: 3535-43. PMID: 14739224
4. Reduced gamma-catenin expression and poor survival in oral squamous cell carcinoma.  |  Närkiö-Mäkelä, M., et al. 2009. Arch Otolaryngol Head Neck Surg. 135: 1035-40. PMID: 19841345
5. Motor neuron position and topographic order imposed by β- and γ-catenin activities.  |  Demireva, EY., et al. 2011. Cell. 147: 641-52. PMID: 22036570
6. γ-Catenin is expressed throughout normal human hematopoietic development and is required for normal PU.1-dependent monocyte differentiation.  |  Morgan, RG., et al. 2013. Leukemia. 27: 2096-100. PMID: 23545990
7. Wnt5a enhances the response of CML cells to Imatinib Mesylate through JNK activation and γ-catenin inhibition.  |  Niu, CC., et al. 2013. Leuk Res. 37: 1532-7. PMID: 23972517
8. Flotillins directly interact with γ-catenin and regulate epithelial cell-cell adhesion.  |  Kurrle, N., et al. 2013. PLoS One. 8: e84393. PMID: 24391950
9. RImmunohistochemical Evaluation of E-cadherin/catenin (alpha-, beta-, gamma-catenin and p120CTN) Complex Expression in Early Gastric Cancer.  |  Jo, TY., et al. 2003. Cancer Res Treat. 35: 16-24. PMID: 26680910
10. Altered gamma-catenin expression correlates with poor survival in patients with bladder cancer.  |  Syrigos, KN., et al. 1998. J Urol. 160: 1889-93. PMID: 9783980

The preferred γ-catenin antibody is γ-catenin Antibody (A-6): sc-514115.