HLA-DQ Antibody (B-K27): sc-65320
- HLA-DQ Antibody (B-K27) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against T4 + CTL clone HG-38
- recommended for detection of HLA-DQ of human origin by IP and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HLA-DQ Antibody (B-K27). This work is in progress.
HLA-DQ Antibody (B-K27) is a mouse monoclonal IgG2a antibody that detects HLA-DQ in human samples through immunoprecipitation (IP) and flow cytometry (FCM) applications. HLA-DQ is a crucial component of the major histocompatibility complex (MHC) class II molecules, which play a vital role in the immune response by presenting processed antigens to CD4+ T lymphocytes. Anti-HLA-DQ antibody (B-K27) is essential for studying the activation of helper T cells, which are pivotal in orchestrating the adaptive immune response. HLA-DQ is primarily located on the surface of antigen-presenting cells, such as B cells and dendritic cells, where HLA-DQ facilitates the recognition of foreign peptides. HLA-DQ′s ability to present a diverse array of peptides is critical for the immune system′s ability to respond to various pathogens. Additionally, HLA-DQ molecules are involved in the regulation of autoimmune responses, and HLA-DQ polymorphisms have been associated with susceptibility to autoimmune diseases, including rheumatoid arthritis. HLA-DQ monoclonal antibody (B-K27) is an invaluable tool for researchers studying immune responses, autoimmune diseases, and the intricate mechanisms of antigen presentation.
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HLA-DQ Antibody (B-K27) References:
- Decreased expression of HLA-DQ and HLA-DR on cells of the monocytic lineage in cystic fibrosis. | Hofer, TP., et al. 2014. J Mol Med (Berl). 92: 1293-304. PMID: 25146850
- HLA-DRB and HLA-DQ genetic variability in patients with aspirin-exacerbated respiratory disease. | Esmaeilzadeh, H., et al. 2015. Am J Rhinol Allergy. 29: e63-9. PMID: 25975240
- HLA-DQ Mismatching: Mounting Evidence for a Role in Kidney Transplant Rejection. | Sarabu, N. and Hricik, DE. 2016. Clin J Am Soc Nephrol. 11: 759-760. PMID: 27034401
- HLA-DQ Mismatching and Kidney Transplant Outcomes. | Leeaphorn, N., et al. 2018. Clin J Am Soc Nephrol. 13: 763-771. PMID: 29685925
- Prediction of HLA-DQ in Deceased Donors and its Clinical Significance in Kidney Transplantation. | Kim, SK., et al. 2021. Ann Lab Med. 41: 190-197. PMID: 33063680
- HLA-DQ-Specific Recombinant Human Monoclonal Antibodies Allow for In-Depth Analysis of HLA-DQ Epitopes. | Bezstarosti, S., et al. 2021. Front Immunol. 12: 761893. PMID: 35069533
- HLA-DQ heterodimers in hematopoietic cell transplantation. | Petersdorf, EW., et al. 2022. Blood. 139: 3009-3017. PMID: 35271697
- HLA-DQ genotype distribution and risk evaluation of celiac disease in Northwest China. | Shi, T., et al. 2023. Scand J Gastroenterol. 58: 471-476. PMID: 36415137
- HLA-DQ Mismatches Lead to More Unacceptable Antigens, Greater Sensitization, and Increased Disparities in Repeat Transplant Candidates. | Isaacson, D., et al. 2022. J Am Soc Nephrol. 33: 2293-2305. PMID: 36450598
- Qualitative, rather than quantitative, differences between HLA-DQ alleles affect HLA-DQ immunogenicity in organ transplantation. | Maguire, C., et al. 2024. HLA. 103: e15455. PMID: 38575370
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-DQ Antibody (B-K27) | sc-65320 | 100 µg/ml | $316.00 |