CD89 Antibody (MIP7c): sc-101472
- CD89 Antibody (MIP7c) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against soluble CD89 of human origin
- recommended for detection of the extracellular EC1 domain of CD89 of human origin by WB, IP and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD89 Antibody (MIP7c). This work is in progress.
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CD89 Antibody (MIP7c) is a mouse monoclonal IgG1 antibody that detects CD89 protein of human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-CD89 antibody (MIP7c) targets the Immunoglobulin alpha Fc receptor (Fc α RI), a crucial glycoprotein predominantly expressed on the surface of immune cells such as neutrophils, monocytes, macrophages, and eosinophils. CD89 (MIP7c) monoclonal antibody recognizes a protein that plays a vital role in the immune response by mediating the endocytosis of IgA-coated antigen complexes, which is essential for the clearance of pathogens and the regulation of antibody production in B cells. The interaction of CD89 with aggregated IgAs, rather than IgGs, highlights CD89′s specificity and importance in immune defense mechanisms. Additionally, the intracellular C-terminus of CD89 can be modified by cytokines, enhancing binding affinity and functional capacity. Notably, polymorphisms in the gene encoding CD89 have been linked to an increased risk of IgA nephropathy, a condition characterized by the deposition of IgA antibodies in the kidney glomeruli, underscoring CD89′s significance in both health and disease.
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CD89 Antibody (MIP7c) References:
- Fc alpha RI/CD89 circulates in human serum covalently linked to IgA in a polymeric state. | van der Boog, PJ., et al. 2002. J Immunol. 168: 1252-8. PMID: 11801662
- Complexes of IgA with FcalphaRI/CD89 are not specific for primary IgA nephropathy. | van der Boog, PJ., et al. 2003. Kidney Int. 63: 514-21. PMID: 12631116
- Monomeric and polymeric IgA show a similar association with the myeloid FcalphaRI/CD89. | Oortwijn, BD., et al. 2007. Mol Immunol. 44: 966-73. PMID: 16675016
- Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy. | Vuong, MT., et al. 2010. Kidney Int. 78: 1281-7. PMID: 20811333
- Anti-inflammatory role of the IgA Fc receptor (CD89): from autoimmunity to therapeutic perspectives. | Ben Mkaddem, S., et al. 2013. Autoimmun Rev. 12: 666-9. PMID: 23201915
- CD89-mediated recruitment of macrophages via a bispecific antibody enhances anti-tumor efficacy. | Li, B., et al. 2017. Oncoimmunology. 7: e1380142. PMID: 29296544
- CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis. | de Tymowski, C., et al. 2019. Cell Rep. 27: 762-775.e5. PMID: 30995475
- Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History. | Wu, H., et al. 2020. Dis Markers. 2020: 8393075. PMID: 32076466
- FcαRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions. | Kroll, KW., et al. 2024. Mucosal Immunol. 17: 692-699. PMID: 38677592
- Blood soluble CD89-IgA complex may be a potential biomarker for predicting multi-organ involvement, especially renal involvement in children with immunoglobulin A vasculitis. | Yu, S., et al. 2024. Int Immunopharmacol. 142: 113063. PMID: 39241523
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD89 Antibody (MIP7c) | sc-101472 | 100 µg/ml | $316.00 |