CD79A Antibody (HM47): sc-20064

CD79A Antibody (HM47) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD79A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD79A (HM47) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD79A protein, also known as immunoglobulin-associated alpha chain, plays a crucial role in B cell antigen receptor (BCR) complex, which is essential for B cell activation and immune response. Located on B cell surfaces, CD79A forms a heterodimer with CD79B, facilitating association with membrane immunoglobulins such as IgM and IgD. This interaction is vital for proper signaling and activation of B cells upon antigen recognition, as cytoplasmic tails of CD79A and CD79B contain immunoreceptor tyrosine-based activation motifs (ITAMs) that recruit and activate tyrosine kinases, leading to downstream signaling cascades. CD79A′s ability to mediate these critical processes underscores CD79A′s importance in adaptive immune response, making anti-CD79A antibody (HM47) an invaluable tool for researchers studying B cell biology and related immunological pathways.

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CD79A Antibody (HM47) References:

1. The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation.  |  Mason, DY., et al. 1992. Eur J Immunol. 22: 2753-6. PMID: 1396979
2. Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene.  |  Ha, HJ., et al. 1992. J Immunol. 148: 1526-31. PMID: 1538135
3. The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells.  |  Mason, DY., et al. 1991. J Immunol. 147: 2474-82. PMID: 1747162
4. The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene.  |  van Noesel, CJ., et al. 1991. J Immunol. 146: 3881-8. PMID: 2033258
5. Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections.  |  Poppema, S., et al. 1987. Am J Pathol. 127: 418-29. PMID: 3296769
6. CD20/CD79a/PAX5/CD3-negative post-transplant lymphoma with aberrant actin and desmin co-expression-a potential differential diagnostic pitfall between PTLD and PTSMT.  |  Suhren, JT., et al. 2022. Ann Hematol. 101: 881-883. PMID: 35179642
7. CD79A work as a potential target for the prognosis of patients with OSCC: analysis of immune cell infiltration in oral squamous cell carcinoma based on the CIBERSORTx deconvolution algorithm.  |  Yao, S., et al. 2023. BMC Oral Health. 23: 411. PMID: 37344840
8. Identification of unique molecular heterogeneity of human CD79, the signaling component of the human B cell antigen receptor (BCR), and synergistic potentiation of the CD79-targeted therapy of B cell tumors by co-targeting of CD79a and CD79b.  |  Seon, BK., et al. 2024. Leuk Res. 136: 107436. PMID: 38232613
9. CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples.  |  Mason, DY., et al. 1995. Blood. 86: 1453-9. PMID: 7632952
10. Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB).  |  Wood, WJ., et al. 1993. Genomics. 16: 187-92. PMID: 8486355
11. Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies.  |  Jones, M., et al. 1993. J Immunol. 150: 5429-35. PMID: 8515069
12. The antigen receptor complex on cord B lymphocytes.  |  Macardle, PJ., et al. 1997. Immunology. 90: 376-82. PMID: 9155644

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD79A Antibody (HM47) has 22 citations in a variety of scientific publications.

Primary antibodies like Anti-CD79A Antibody (HM47) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD79A Antibody (HM47) Specifications

Alternate Product Name: CD79A (Ig-Alpha)

Product Clone Name: HM47

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CD79A

Epitope Species: human

Product Reactivity/Detection: CD79A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 22 citations in various scientific publications

Available Conjugates/Forms for CD79A Antibody (HM47): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin