CD45RC Antibody (GL24): sc-52495
- CD45RC Antibody (GL24) is a rat monoclonal IgM provided at 100 µg/ml
- recommended for detection of CD45RC of mouse origin by WB, IP and FCM
- available conjugated to phycoerythrin for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD45RC Antibody (GL24). This work is in progress.
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CD45RC Antibody (GL24) is a rat monoclonal IgM antibody that detects CD45RC in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD45RC, also known as PTPRC, is a transmembrane glycoprotein predominantly expressed in hematopoietic cells, where CD45RC plays a crucial role in immune signaling. CD45RC functions as a phosphotyrosine phosphatase, which is essential for regulating tyrosine phosphorylation events initiated by the T cell receptor (TCR) and CD3 complex. CD45RC activity is localized within its conserved intracellular domain, allowing CD45RC to modulate signaling pathways activated by Src and Syk family protein tyrosine kinases, such as Lck, Fyn, and ZAP-70. These kinases are critical for T cell activation and proliferation, making CD45RC a key player in immune response. Multiple isoforms of CD45RC, arising from alternative splicing, further highlight the complexity of CD45RC regulation and function within the immune system, as different isoforms can influence T cell activation and differentiation. Anti-CD45RC antibody (GL24) serves as an invaluable tool for researchers studying T cell biology and signaling mechanisms governing immune responses.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD45RC Antibody (GL24) | sc-52495 | 100 µg/ml | $316.00 |