CD1A Antibody (NA1/34): sc-53035

CD1A Antibody (NA1/34) is a mouse monoclonal IgG2a light chain antibody that detects CD1A in human samples through applications such as immunofluorescence (IF) and flow cytometry (FCM). CD1A plays a crucial role in the immune system as a lipid antigen-presenting molecule, which is essential for the activation of T lymphocytes. CD1A is primarily located on the surface of Langerhans cells, a specialized type of dendritic cell found in the skin, where CD1A is involved in the recognition and presentation of lipid antigens to T cells. CD1A expression on these cells is particularly important for initiating immune responses to lipid-based pathogens, thereby influencing the body′s ability to respond to infections and maintain immune homeostasis. Additionally, CD1A serves as a marker for Langerhans cell histiocytosis, a rare disorder characterized by the proliferation of Langerhans cells, highlighting CD1A′s significance in both normal immune function and disease states. Anti-CD1A antibody (NA1/34) is an invaluable tool for researchers studying immune responses, dendritic cell biology, and related pathologies.

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CD1A Antibody (NA1/34) References:

1. Self-regressing S100-negative CD1a-positive cutaneous histiocytosis.  |  Tardío, JC., et al. 2013. Am J Dermatopathol. 35: e57-9. PMID: 23334517
2. A polymorphism in human CD1A is associated with susceptibility to tuberculosis.  |  Seshadri, C., et al. 2014. Genes Immun. 15: 195-8. PMID: 24500401
3. Cracking the code of skin inflammation with CD1a.  |  Amagai, M. 2016. Nat Immunol. 17: 1133-4. PMID: 27648537
4. Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells.  |  Lim, KPH., et al. 2020. Blood Adv. 4: 87-99. PMID: 31899802
5. Human skin is colonized by T cells that recognize CD1a independently of lipid.  |  Cotton, RN., et al. 2021. J Clin Invest. 131: PMID: 33393500
6. The role of CD1a expression in the diagnosis of cutaneous leishmaniasis, its relationship with leishmania species and clinicopathological features.  |  Karabulut, YY., et al. 2021. Dermatol Ther. 34: e14977. PMID: 33991375
7. Infiltration of CD1a-positive dendritic cells in advanced laryngeal cancer correlates with unfavorable outcomes post-laryngectomy.  |  Minesaki, A., et al. 2021. BMC Cancer. 21: 973. PMID: 34461859
8. Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status.  |  Gama-Cuellar, AG., et al. 2022. J Appl Oral Sci. 30: e20210702. PMID: 35584505
9. Human Skin T Cells Express Conserved T-Cell Receptors that Cross-React with Staphylococcal Superantigens and CD1a.  |  Bryan, E., et al. 2024. J Invest Dermatol. 144: 833-843.e3. PMID: 37951348
10. Integrated Analysis of CD1A Immune Infiltration and Competing Endogenous RNA Networks in COAD.  |  Xu, H., et al. 2024. Int J Gen Med. 17: 2037-2053. PMID: 38751492

The preferred CD1A antibody is CD1A Antibody (O10): sc-18885.