CD1A Antibody (NA1/34-HLK): sc-80548

CD1A Antibody (NA1/34-HLK) is a mouse monoclonal IgG2a antibody that detects CD1A in human samples through applications such as immunofluorescence (IF) and flow cytometry (FCM). CD1A is a crucial member of the CD1 multigene family, which encodes five forms of the CD1 T-cell surface glycoprotein, and plays a significant role in the immune system by presenting lipid antigens to T lymphocytes. CD1A protein is primarily located on the surface of Langerhans cells, a specialized type of dendritic cell found in the skin, where CD1A is essential for the recognition of lipid-based antigens and the activation of T cells. CD1A expression on these cells is particularly important for the immune response to certain pathogens and for the development of Langerhans cell histiocytosis (LCH), a condition characterized by the proliferation of Langerhans cells. CD1A′s interaction with adaptor-protein complexes and chaperones is vital for proper trafficking and function, ensuring that lipid antigens are effectively presented to T cells. The human CD1 genes, including CD1A, are closely linked in a cluster on chromosome 1q23.1, highlighting their evolutionary significance and functional interdependence. Anti-CD1A antibody (NA1/34-HLK) is an invaluable tool for researchers studying immune responses and related disorders, providing insights into the complex mechanisms of antigen presentation and T cell activation.

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CD1A Antibody (NA1/34-HLK) References:

1. Distribution of CD1a-positive cells in psoriatic skin during the evolution of the lesions.  |  Bieber, T. and Braun-Falco, O. 1989. Acta Derm Venereol. 69: 175-8. PMID: 2564240
2. CD1a+ and CD83+ Langerhans cells are reduced in lower lip squamous cell carcinoma.  |  Gomes, JO., et al. 2016. J Oral Pathol Med. 45: 433-9. PMID: 26661374
3. Isolated Clear Epidermal Keratinocytes Bearing CD1a +ve Amastigotes.  |  Magdaleno-Tapial, J., et al. 2020. Am J Dermatopathol. 42: 41-42. PMID: 31188141
4. Immunohistochemical analysis of the aggregation of CD1a-positive dendritic cells in resected specimens and its association with surgical outcomes for patients with gallbladder cancer.  |  Kai, K., et al. 2021. Transl Oncol. 14: 100923. PMID: 33129106
5. Distribution of CD1a-positive cells is not different between pseudolymphomatous folliculitis and primary cutaneous marginal zone lymphoma.  |  Shojiguchi, N., et al. 2021. J Dermatol. 48: 464-469. PMID: 33326629
6. Bone marrow involvement by CD1a-negative langerhans cell histiocytosis with associated hemophagocytosis.  |  Al Moosawi, M. and Marcon, K. 2021. Int J Hematol. 113: 471-472. PMID: 33404985
7. Diagnostic usefulness of immunohistochemical evaluation of CD1a antigen and polyclonal anti-leishmania antibodies in cutaneous leishmaniasis.  |  Lopez-Trujillo, E., et al. 2021. Histol Histopathol. 36: 567-576. PMID: 33665791
8. A Novel Bispecific T-Cell Engager (CD1a x CD3ε) BTCE Is Effective against Cortical-Derived T Cell Acute Lymphoblastic Leukemia (T-ALL) Cells.  |  Riillo, C., et al. 2022. Cancers (Basel). 14: PMID: 35740552
9. Oral lupus erythematosus: Immunohistochemical evaluation of CD1a, CD21, CD123, and langerin expression in dendritic cells.  |  Marques, ERMDC., et al. 2024. J Cutan Pathol. 51: 368-378. PMID: 38287771
10. Evaluating CD1a Immunohistochemistry for Tegumentary Leishmaniasis Diagnosis in the New World: A Focus on Colombia.  |  Aristizábal-Parra, LK., et al. 2025. Am J Dermatopathol. 47: 197-205. PMID: 39412339

The preferred CD1A antibody is CD1A Antibody (O10): sc-18885.