p55 Antibody (51-B): sc-130381

p55 Antibody (51-B) is a mouse monoclonal IgG1 antibody that detects p55 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. p55 is an extensively palmitoylated erythrocyte membrane protein and a member of the MAGUK family, known for its critical role in maintaining the structural integrity and functionality of the erythrocyte membrane. Anti-p55 antibody (51-B) exhibits a unique resistance to salt extraction, which enhances its affinity for the plasma membrane, thereby contributing to the stability of erythrocytes under various physiological conditions. p55 contains several important structural features, including a PDZ/DHR domain and a conserved SH-3 domain that appears to suppress the tyrosine kinase activity of various oncoproteins, which is vital for regulating cellular signaling pathways. Additionally, p55 possesses a 39-amino acid motif that binds to the cytoskeletal protein 4.1R, facilitating interactions that are essential for maintaining cell shape and mechanical properties. The guanylate kinase-like domain further underscores its multifunctional nature, suggesting a role in cellular signaling and membrane dynamics. Notably, p55 interacts with glycophorin C and 4.1R, indicating its involvement in the dynamic regulation of the erythrocyte membrane, which is crucial for proper red blood cell function. Furthermore, p55 gene expression in vivo may be associated with a CpG island, and p55 is constitutively expressed in K562 erythroleukemia cells during erythropoiesis, undergoing a two-fold amplification upon induction, highlighting its potential significance in hematopoietic processes. p55 monoclonal antibody (51-B) is an invaluable tool for researchers investigating erythrocyte biology and related disorders.

The preferred p55 antibody is p55 Antibody (A-7): sc-374506.