Gephyrin Antibody (45): sc-135920
- Gephyrin Antibody (45) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 569-726 of Gephyrin of rat origin
- recommended for detection of Gephyrin of mouse, rat, human and Drosophila origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Gephyrin Antibody (45). This work is in progress.
QUICK LINKS
SEE ALSO...
Gephyrin Antibody (45) is a mouse monoclonal IgG1 antibody that detects Gephyrin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Gephyrin is a crucial microtubule-associated protein predominantly expressed in the brain, where Gephyrin plays a vital role in the postsynaptic localization of inhibitory glycine receptors, effectively anchoring these receptors to subsynaptic microtubules. This anchoring is essential for maintaining synaptic stability and regulating inhibitory neurotransmission, which is critical for proper neuronal function and communication. Gephyrin is not only found in the brain but is also expressed in various mammalian tissues, highlighting Gephyrin′s importance in diverse physiological processes. Notably, Gephyrin exists in at least five splice variants, each differing in molecular weight, which may contribute to Gephyrin′s functional diversity and regulatory mechanisms in synaptic transmission. Anti-Gephyrin antibody (45) is an invaluable tool for researchers investigating synaptic dynamics and the molecular underpinnings of neurotransmission.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Gephyrin Antibody (45) References:
- Synaptic and extrasynaptic GABAA receptor and gephyrin clusters. | Christie, SB., et al. 2002. Prog Brain Res. 136: 157-80. PMID: 12143379
- Modulation of gephyrin-glycine receptor affinity by multivalency. | Maric, HM., et al. 2014. ACS Chem Biol. 9: 2554-62. PMID: 25137389
- Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission. | Maric, HM., et al. 2017. Nat Chem Biol. 13: 153-160. PMID: 27893705
- Gephyrin suppresses lung squamous cell carcinoma development by reducing mTOR pathway activation. | Zhang, X., et al. 2019. Cancer Manag Res. 11: 5333-5341. PMID: 31239782
- Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation. | Bai, G., et al. 2021. Cell Res. 31: 312-325. PMID: 33139925
- Impaired formation of high-order gephyrin oligomers underlies gephyrin dysfunction-associated pathologies. | Kim, S., et al. 2021. iScience. 24: 102037. PMID: 33532714
- Reciprocal stabilization of glycine receptors and gephyrin scaffold proteins at inhibitory synapses. | Chapdelaine, T., et al. 2021. Biophys J. 120: 805-817. PMID: 33539789
- A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology. | Campbell, BFN., et al. 2022. Elife. 11: PMID: 36314779
- The gephyrin scaffold modulates cortical layer 2/3 pyramidal neuron responsiveness to single whisker stimulation. | Tsai, YC., et al. 2024. Sci Rep. 14: 4169. PMID: 38379020
- miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity. | Welle, TM., et al. 2024. EMBO Rep. 25: 5141-5168. PMID: 39294503
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gephyrin Antibody (45) | sc-135920 | 50 µg/0.5 ml | $316.00 |