PLC γ1 Antibody (B-4): sc-374467
- PLC γ1 Antibody (B-4) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 75-115 near the N-terminus of PLC γ1 of human origin
- recommended for detection of PLC γ1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- See PLC γ1 (E-12): sc-7290 for PLC γ1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PLC γ1 Antibody (B-4) for WB applications. These reagents are now offered in bundles with PLC γ1 Antibody (B-4) (see ordering information below).
PLC γ1 Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects phospholipase C gamma 1 (PLC γ1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PLC γ1 plays a pivotal role in receptor-mediated signal transduction by generating second messengers inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate, which are essential for various cellular processes. PLC γ1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes, and fibroblasts of the interstitial tissue, highlighting importance in respiratory function and cellular communication. Notably, PLC γ1 interacts with actin-regulatory protein Villin, which is tyrosine phosphorylated and associates with PLC γ1 in the brush border of intestinal epithelial cells, thereby regulating activity and influencing cellular adhesion through Integrin α1/β1. Rapid activation of PLC γ1 in response to growth factor stimulation underscores a critical role in regulating cell proliferation and differentiation, as well as potential protective function during oxidative stress responses. Anti-PLC γ1 antibody (B-4) serves as an invaluable tool for researchers studying signal transduction pathways and cellular dynamics.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PLC γ1 Antibody (B-4) | sc-374467 | 200 µg/ml | $316.00 | |||
PLC γ1 Antibody (B-4): m-IgG Fc BP-HRP Bundle | sc-540459 | 200 µg Ab; 10 µg BP | $354.00 | |||
PLC γ1 Antibody (B-4): m-IgG1 BP-HRP Bundle | sc-542138 | 200 µg Ab; 20 µg BP | $354.00 | |||
PLC γ1 (B-4) Neutralizing Peptide | sc-374467 P | 100 µg/0.5 ml | $68.00 |