KAT I Antibody (B-8): sc-271709
- KAT I Antibody (B-8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 341-377 within an internal region of KAT I of human origin
- recommended for detection of KAT I isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KAT I Antibody (B-8) for WB and IHC(P) applications. These reagents are now offered in bundles with KAT I Antibody (B-8) (see ordering information below).
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KAT I Antibody (B-8) is a mouse monoclonal IgG2a antibody that detects KAT I in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). KAT I, a member of the class-I pyridoxal-phosphate-dependent aminotransferase family, is primarily located in the cytoplasm and plays a crucial role in glutamine catabolism. KAT I (B-8) antibody recognizes a protein that catalyzes the transamination of L-kynurenine to produce kynurenic acid, which serves as a neuroprotective and anticonvulsant metabolite derived from tryptophan. This metabolic pathway is essential for maintaining synaptic transmission and has been linked to various neurological disorders, including schizophrenia and Huntington′s disease. KAT I exists in three isoforms, with isoform 1 being the full-length protein, while isoform 2 and isoform 3 exhibit deletions in specific amino acid regions. The structural integrity and functional homodimerization of KAT I are vital for enzymatic activity, underscoring the importance in both normal physiological processes and disease states. Anti-KAT I antibody (B-8) is an invaluable tool for researchers investigating the role of KAT I in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KAT I Antibody (B-8) | sc-271709 | 200 µg/ml | $316.00 | |||
KAT I Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-537685 | 200 µg Ab; 10 µg BP | $354.00 | |||
KAT I Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-535031 | 200 µg Ab; 40 µg BP | $354.00 | |||
KAT I Antibody (B-8): m-IgG2a BP-HRP Bundle | sc-548086 | 200 µg Ab; 10 µg BP | $354.00 | |||
KAT I (B-8) Neutralizing Peptide | sc-271709 P | 100 µg/0.5 ml | $68.00 |