Neuregulin-3/NRG3 Antibody Summary
Immunogen |
Peptide with sequence C-RNEIQRDSALTK corresponding to C-Terminus according to NP_001010848.2. |
Epitope |
RNEIQRDSALTK |
Predicted Species |
Canine (100%). Backed by our 100% Guarantee. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Goat |
Gene |
NRG3 |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Peptide ELISA Detection limit 1:64000
- Western Blot 0.1 - 0.3 ug/ml
|
Application Notes |
WB: Approx. 75 kDa band observed in human brain (cerebellum) lysates and in mouse and rat brain lysates (calculated MW of 75.0 kDa band according to NP_001010848.2). An additional band of unknown identity was also consistently observed at 37 kDa. This band was successfully blocked by incubation with the immunizing peptide. |
Publications |
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Packaging, Storage & Formulations
Storage |
Store at -20C. Avoid freeze-thaw cycles. |
Buffer |
Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA |
Preservative |
0.02% Sodium Azide |
Concentration |
0.5 mg/ml |
Purity |
Immunogen affinity purified |
Alternate Names for Neuregulin-3/NRG3 Antibody
Background
NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Publications for Neuregulin-3/NRG3 Antibody (NB100-61670)(1)
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