Neuregulin-3/NRG3 Antibody

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Western Blot: Neuregulin-3/NRG3 Antibody [NB100-61670] - Analysis of Neuregulin 3 in Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer) using this antibody at 0.3 ug/ml. Primary incubation was 1 hour. ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, CaSpecies Glossary
Applications WB, ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml
Datasheet
Reviews & Publications
Protocols & FAQs
Support & Research

Neuregulin-3/NRG3 Antibody Summary

Immunogen
Peptide with sequence C-RNEIQRDSALTK corresponding to C-Terminus according to NP_001010848.2.
Epitope
RNEIQRDSALTK
Predicted Species
Canine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
NRG3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Peptide ELISA Detection limit 1:64000
  • Western Blot 0.1 - 0.3 ug/ml
Application Notes
WB: Approx. 75 kDa band observed in human brain (cerebellum) lysates and in mouse and rat brain lysates (calculated MW of 75.0 kDa band according to NP_001010848.2). An additional band of unknown identity was also consistently observed at 37 kDa. This band was successfully blocked by incubation with the immunizing peptide.
Publications
Read Publication using NB100-61670.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Neuregulin-3/NRG3 Antibody

  • HRG3
  • neuregulin 3 variant 1
  • neuregulin 3 variant 10
  • neuregulin 3 variant 11
  • neuregulin 3 variant 12
  • neuregulin 3 variant 13
  • neuregulin 3 variant 14
  • neuregulin 3 variant 3
  • neuregulin 3 variant 4
  • neuregulin 3 variant 5
  • neuregulin 3 variant 6
  • neuregulin 3 variant 7
  • neuregulin 3 variant 8
  • neuregulin 3 variant 9
  • neuregulin 3
  • Neuregulin3
  • Neuregulin-3
  • neuregulin-3-like polypeptide
  • NRG3
  • pro-neuregulin-3, membrane-bound isoform
  • pro-NRG3

Background

NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NRG3
Entrez
Uniprot