Aldehyde dehydrogenase 3-A1/ALDH3A1 Antibody (A-5): sc-373688

ALDH3A1 Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects aldehyde dehydrogenase 3A1 (ALDH3A1) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALDH3A1 plays a crucial role in the metabolism of aldehydes, particularly in the detoxification of harmful compounds, which is vital for cellular health and protection against oxidative stress. This enzyme is predominantly located in the cytoplasm and forms a homodimer that preferentially oxidizes aromatic aldehyde substrates, making ALDH3A1 essential for the metabolism of various endogenous and exogenous compounds. ALDH3A1 is particularly significant in tissues such as the stomach, where ALDH3A1 helps mitigate the effects of dietary aldehydes, and ALDH3A1 upregulation in certain tumors suggests a potential role in cancer metabolism and resistance to chemotherapy. Anti-ALDH3A1 antibody (A-5) enables researchers to gain insights into the expression and function of this important enzyme in various biological contexts, enhancing our understanding of its implications in health and disease.

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Aldehyde dehydrogenase 3-A1/ALDH3A1 Antibody (A-5) References:

1. Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage.  |  Pappa, A., et al. 2003. Free Radic Biol Med. 34: 1178-89. PMID: 12706498
2. Arachidonic acid suppresses growth of human lung tumor A549 cells through down-regulation of ALDH3A1 expression.  |  Muzio, G., et al. 2006. Free Radic Biol Med. 40: 1929-38. PMID: 16716894
3. Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1.  |  Estey, T., et al. 2007. J Biol Chem. 282: 4382-4392. PMID: 17158879
4. Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice.  |  Lassen, N., et al. 2007. J Biol Chem. 282: 25668-76. PMID: 17567582
5. Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity.  |  Parajuli, B., et al. 2014. Chembiochem. 15: 701-12. PMID: 24677340
6. ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output.  |  Terzuoli, E., et al. 2019. Cancers (Basel). 11: PMID: 31817719
7. ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway.  |  Qu, Y., et al. 2020. J Cancer. 11: 2621-2631. PMID: 32201532
8. Chronic restraint stress promotes oral squamous cell carcinoma development by inhibiting ALDH3A1 via stress response hormone.  |  Luo, S., et al. 2024. BMC Oral Health. 24: 43. PMID: 38191346
9. Corneal strain influences keratocyte proliferation and migration through upregulation of ALDH3A1 expression.  |  Zhang, Q., et al. 2024. FASEB J. 38: e70236. PMID: 39652089
10. ALDH3A1-mediated detoxification of reactive aldehydes contributes to distinct muscle responses to denervation and Amyotrophic Lateral Sclerosis progression.  |  Li, A., et al. 2024. bioRxiv.. PMID: 39677625

The preferred Aldehyde dehydrogenase 3-A1/ALDH3A1 antibody is Aldehyde dehydrogenase 3-A1/ALDH3A1 Antibody (G-2): sc-376089.