ADH Antibody (G-7): sc-133207

ADH Antibody (G-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects ADH protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-ADH antibody (G-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The alcohol dehydrogenase family, to which ADH belongs, plays a crucial role in metabolizing a diverse range of substrates, such as ethanol, retinol, and other aliphatic alcohols, which is vital for maintaining metabolic homeostasis. Specifically, ADH structure is composed of several homo- and heterodimers formed by alpha, beta, and gamma subunits, which allows for a high degree of enzymatic flexibility and substrate specificity. This structural diversity enables ADH to efficiently catalyze the reversible conversion of organic alcohols to ketones or aldehydes in the presence of the coenzyme NAD. ADH physiological importance in the liver is underscored by ADH role in detoxifying ethanol produced by intestinal microorganisms, thereby preventing potential toxicity and contributing to overall metabolic regulation.

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ADH Antibody (G-7) References:

1. Alcohol dehydrogenase (ADH) isoenzyme activity in the sera of patients with Helicobacter pylori infection.  |  Jelski, W., et al. 2007. Dig Dis Sci. 52: 1513-6. PMID: 17404875
2. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the cancer diseases.  |  Jelski, W. and Szmitkowski, M. 2008. Clin Chim Acta. 395: 1-5. PMID: 18505683
3. Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization.  |  Tsukahara, M. and Yoshida, A. 1989. Genomics. 4: 218-20. PMID: 2737681
4. Elevated Adenosine Dehydrogenase (ADH) and Positive Tuberculin Test Firstly Misdiagnosed as Tuberculous Pleural Effusion Finally Proved as Pleural Mesothelial Sarcoma by Thoracoscopic Biopsy Pathology: a Case Report and Literature Review.  |  Li, WQ., et al. 2019. Clin Lab. 65: PMID: 31625358
5. Renin, antidiuretic hormone (ADH), and ADH receptor levels in cerebral salt wasting associated with tuberculous meningitis.  |  Tripathi, A., et al. 2022. Neurol Sci. 43: 3361-3369. PMID: 34988719
6. Telmisartan anti-cancer activities mechanism through targeting N-cadherin by mimicking ADH-1 function.  |  Khorsand, M., et al. 2022. J Cell Mol Med. 26: 2392-2403. PMID: 35224849
7. The alcohol dehydrogenase isoenzyme (ADH I) as a marker of intrahepatic cholestasis of pregnancy.  |  Piechota, J., et al. 2022. Sci Rep. 12: 11071. PMID: 35773406
8. An Assessment of the Serum Activity of ADH and ALDH in Patients with Primary Biliary Cholangitis.  |  Wolszczak-Biedrzycka, B., et al. 2022. Arch Immunol Ther Exp (Warsz). 71: 2. PMID: 36575342
9. Vortioxetine-associated syndrome of inappropriate ADH secretion.  |  Sugunan, S., et al. 2025. BMJ Case Rep. 18: PMID: 40010753
10. Studies on the subunit structure and molecular size of the human alcohol dehydrogenase isozymes determined by the different loci, ADH1, ADH2, and ADH3.  |  Smith, M., et al. 1973. Ann Hum Genet. 36: 401-14. PMID: 4748759

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ADH Antibody (G-7) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-ADH Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ADH Antibody (G-7) Specifications

Alternate Product Name: ADH

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-300

Epitope Target: ADH

Epitope Species: human

Product Reactivity/Detection: ADHα, ADHβ and ADHγ of human origin and Adh1 of mouse and rat origin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for ADH Antibody (G-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin