LRRTM3 Antibody - BSA Free

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Western Blot: LRRTM3 Antibody [NBP1-76529] - Mouse brain tissue lysate with LRRTM3 antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1 mg/ml

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Reviews & Publications
Protocols & FAQs
Support & Research

LRRTM3 Antibody - BSA Free Summary

Immunogen
Antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human LRRTM3. The immunogen is located within the last 50 amino acids of LRRTM3. Amino Acid Squence: SFETNAQEDTMETHLETE
Specificity
At least two isoforms of LRRTM3 are known to exist; this antibody will only detect the larger isoform.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LRRTM3
Purity
Peptide affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 2.5 ug/ml
  • Immunohistochemistry-Paraffin 2.5 ug/ml
  • Western Blot 0.5 ug/ml
Control Peptide
LRRTM3 Peptide (NBP1-76529PEP)
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Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for LRRTM3 Antibody - BSA Free

  • leucine rich repeat transmembrane neuronal 3
  • leucine-rich repeat transmembrane neuronal protein 3
  • LRRTM3
  • MGC131810

Background

The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the Abeta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Abeta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LRRTM3
Uniprot