Novus Biologicals uses cookies to provide you with a great website experience. By continuing to use this website you acknowledge this and agree to our cookie policy.
Note: Mouseover a species abbreviation on the product page to display the fullname.
Images
Western Blot: BRCA2 Antibody (5F6) [NBP1-41189] - Whole cell extract (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with BRCA2 antibody [5F6] diluted at 1:1000. The HRP-conjugated anti-mouse IgG ...read more
Western Blot: BRCA2 Antibody (5F6) [NBP1-41189] - Whole cell extract (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with BRCA2 antibody [5F6] diluted at 1:1000. The HRP-conjugated anti-mouse IgG ...read more
384 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using NBP1-41189 in the following applications:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Purity
Protein G purified
Alternate Names for BRCA2 Antibody (5F6) - Azide and BSA Free
BRCA1/BRCA2-containing complex, subunit 2
BRCA2
BRCC2
breast and ovarian cancer susceptibility gene, early onset
breast cancer 2 tumor suppressor
breast cancer 2, early onset
breast cancer susceptibility protein BRCA2
breast cancer type 2 susceptibility protein
BROVCA2
FACD
FAD
FAD1
FANCB
FANCD
FANCD1Fanconi anemia, complementation group D1
Fanconi anemia group D1 protein
GLM3
PNCA2
Background
BRCA2-5F6 recognizes the BRCA2 gene product, a 390kDa nuclear protein. The BRCA2 gene was originally isolated based on its importance in the predisposition of women to early-onset breast and ovarian cancers, suggesting mutations affect its tumor suppressor-like activity. Targeted disruption of the BRCA2 gene in mice and binding of Rad51 to its carboxyl terminus have indicated an involvement in DNA recombination and double strand break repair.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FANCD2 and DNA damage repair Fanconi anemia (FA) is a genetically inherited disorder that yields cytogenetic instability, hypersensitivity to DNA crosslinking compounds and defective DNA repair. A variety of genes have been identified within the FA pathway that are referred t... Read full blog post.
Breast Cancer Infographic Breast cancer is caused by malignant cells developing in breast tissue. It is the most commonly diagnosed cancer in women, but advancements in treatment options have seen the death rate decline since the 1990s. Common warning signs of breast cancer in... Read full blog post.
RAD51: The cell's 'Mr. Fix-it' RAD51 is a recombinase protein encoded by RAD51 gene in humans. Human RAD51 family members are highly similar to bacterial RecA and yeast Rad51, both biochemically and structurally. It is a 339-amino acid protein that plays an important role in homolo... Read full blog post.
Breast Cancer and RAD51L1 Antibodies In the United States, breast cancer is one of the most common cancers and the second leading cause of cancer related deaths in women. According to the American Cancer Society's most recent estimates for breast cancer in the United States, there are ab... Read full blog post.
Determining DMC1's role in Homologus Recombination The DMC1 gene encodes a 36.7 kDa nuclear protein involved in meiotic homologous recombination. This recombinase is functionally related to the yeast RAD51 and E. coli RecA genes. In contrast to RAD51, which functions in both mitotic and meiotic recomb... Read full blog post.
Rad51 Antibody Reveals a Canine Model for Human Breast Cancer Our antibody catalog includes an extensive range of Rad51 antibody reagents. Encoded by the RAD51 gene, the Rad51 protein plays a vital role in DNA repair, interacting with several other proteins, including BRCA1 and BRCA2, to effect homologous recomb... Read full blog post.
Fanconi Antibodies and Cancer Research We at Novus Biologicals have an extensive antibody databasedevoted to the 13 Fanconi anaemia complementation (FANC) genes, which are involved in the recognition and repair of damaged DNA.The core complex of 8 proteins (FANCA, B, C, E, F, G, L and M)... Read full blog post.
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
=
÷
Review this Product
Be the first to review our BRCA2 Antibody (5F6) - Azide and BSA Free and receive a gift card or discount.
![Western Blot: BRCA2 Antibody (5F6) [NBP1-41189] - Whole cell extract (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with BRCA2 antibody [5F6] diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (NBP2-19382) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.](http://images.novusbio.com/fullsize/antibody/nbp1-41189_mouse-monoclonal-brca2-antibody-5f6-western-blot-2962023104449..jpg "Western Blot: BRCA2 Antibody (5F6) [NBP1-41189] - Whole cell extract (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with BRCA2 antibody [5F6] diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (NBP2-19382) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.")
![SDS-PAGE ErbB2/Her2 [Unconjugated]](https://images.novusbio.com/images2/ErbB2_1129-ER_70.jpg)
![Bioactivity ErbB2/Her2 [Unconjugated]](https://images.novusbio.com/images2/1129-er_recombinant-human-erbb2-her2-fc-chimera-protein-cf-bioactivity-7122020142841.jpg)
![SDS-Page: Mouse IgG1 Isotype Control (MG1) [NBP1-97005] - Lane 1: , Non-reduced. M: Opal Pre-stained Ladder. Lane 2: , Reduced. Load: 1.0 ug per lane. Predicted/Observed: 120 kDa Non-reduced, 55 and 25 Reduced.](https://images.novusbio.com/images/Mouse-IgG1-Isotype-Control-MG1-SDS-Page-NBP1-97005-img0002.jpg "SDS-Page: Mouse IgG1 Isotype Control (MG1) [NBP1-97005] - Lane 1: , Non-reduced. M: Opal Pre-stained Ladder. Lane 2: , Reduced. Load: 1.0 ug per lane. Predicted/Observed: 120 kDa Non-reduced, 55 and 25 Reduced.")