Hemoglobin β Antibody (21): sc-130321

Hemoglobin β Antibody (21) is a mouse monoclonal IgG1 kappa light chain antibody specifically raised against recombinant human Hemoglobin β. Hemoglobin β, also known as Hemoglobin subunit beta or β-globin, is a vital component of adult hemoglobin (HbA), which comprises two alpha (α) and two beta (β) globin chains forming a tetramer essential for oxygen transport in the bloodstream. Each β-globin chain binds a heme group containing an iron ion, enabling the efficient binding and release of oxygen molecules. Post-translational modifications (PTMs) of Hemoglobin β, such as glycation, the non-enzymatic attachment of glucose molecules, can significantly impact function. Elevated levels of glycated hemoglobin (HbA1c) are clinically significant in conditions like diabetes mellitus, where they serve as indicators of poor glucose control. These modifications can alter structure and function, affecting oxygen delivery and contributing to disease pathogenesis. Anti-Hemoglobin β antibody (21) has been validated for use in western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA), making this tool invaluable for studying Hemoglobin β expression and post-translational modifications. By detecting alterations in Hemoglobin β, researchers can gain insights into oxygen delivery mechanisms and the impact of metabolic disorders on hemoglobin functionality. Hemoglobin β monoclonal antibody (21) facilitates advanced research in hematology and related biomedical fields.

The preferred Hemoglobin β antibody is Hemoglobin β Antibody (37-8): sc-21757.